NCT00869817From ClinicalTrials.govRecruiting

Dominantly Inherited Alzheimer Network (DIAN)

Alzheimer's Disease

At a glance

Phase: Phase not stated
Study type: Observational
Sponsor: Washington University School of Medicine
Enrolment target: 700
Started: January 2009
Main results due: September 2026
Study sites: 26
Registry updated: 25 September 2026

Can you take part?

Aged 18 years and over.
Open to any sex.
Healthy volunteers can take part.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria

Inclusion Criteria:

* Written informed consent obtained from participant and collateral source prior to any study-related procedures.
* Aged 18 (inclusive) or older and the child of an affected individual (clinically or by testing) in a pedigree with a known mutation for ADAD.
* Cognitively normal to very mild or mild cognitive impairment (CDR score range 0-1.0). Primary enrollment will focus on the recruitment of asymptomatic adult children who are more than 15 years younger than the estimated age of symptom onset. Enrollment of new participants with moderate cognitive impairment is allowed with the prior approval of the DIAN Coordinating Center.
* Has two persons who are not their full-blooded siblings who can serve as collateral sources for the study.
* Fluent in a language approved by the DIAN Coordinating Center at about the 6th grade level (international equivalent) or above.

Exclusion Criteria:

* Under age 18
* Medical or psychiatric illness that would interfere in completing initial and follow-up visits
* Requires nursing home level care
* Has no one who can serve as a study informant

What this study is about

In the sponsor’s own words, from the registry.

The purpose of this study is to identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.

Study sites(26)

Mayo Clinic Jacksonville
Jacksonville, Florida, United States
Recruiting
Indiana University-Indiana Alzheimer Disease Center
Indianapolis, Indiana, United States
Recruiting
Brigham and Women's Hospital
Boston, Massachusetts, United States
Recruiting
Washington University in St. Louis School of Medicine
St Louis, Missouri, United States
Recruiting
Columbia University
New York, New York, United States
Suspended
University of Pittsburgh
Pittsburgh, Pennsylvania, United States
Recruiting
Butler Hospital
Providence, Rhode Island, United States
Recruiting
University of Washington
Seattle, Washington, United States
Recruiting
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI)
Salta, Salta Province, Argentina
Recruiting
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia" (FLENI) Instituto de Investigaciones Neurológicas Raúl Correa
Buenos Aires, Argentina
Recruiting
Neuroscience Research Australia
Sydney, New South Wales, Australia
Recruiting
Mental Health Research Institute, University of Melbourne
Melbourne, Victoria, Australia
Suspended
Sir James McCusker Alzheimer's Disease Research Unit, Edith Cowan University
Perth, Western Australia, Australia
Recruiting
Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo
São Paulo, São Paulo, Brazil
Recruiting
McGill University Research Centre for Studies in Aging
Verdun, Quebec, Canada
Not yet recruiting
Grupo Neurociencias de Antioquia
Medellín, Colombia, Colombia
Recruiting
German Center for Neurodegenerative Diseases (DZNE) Munich, and University Hospital Ludwig-Maximilians-Universitat (LMU) Munich
Munich, Germany
Recruiting
German Center for Neurodegenerative Diseases (DZNE) Tübingen and Hertie-Institute for Clinical Brain Research, University of Tübingen
Tübingen, Germany
Recruiting
Niigata University
Niigata, Japan
Recruiting
Osaka City University
Osaka, Japan
Suspended
Tokyo University
Tokyo, Japan
Recruiting
Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suarez"
Mexico City, Mexico City, Mexico
Recruiting
Amsterdam UMC
Amsterdam, Netherlands
Recruiting
Asan Medical Center
Seoul, Songpa-Gu, South Korea
Recruiting
Hospital Clinic Barcelona
Barcelona, Catalonia, Spain
Suspended
Institute of Neurology, Queen Square
London, United Kingdom
Recruiting

Showing 26 of 26 sites. 21 of the 26 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT00869817. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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