Quantitative Measurement and Correlates of the Latent HIV Reservoir in Virally Suppressed Ugandans

* INCLUSION CRITERIA:

  1. At least 18 years of age
  2. Hemoglobin \>11g/dL as assessed by fingerstick rapid test
  3. Weight \>40 kilograms
  4. A historical diagnosis of HIV infection as indicated by any positive serological test (ELISA, HIV rapid test, or Western Blot)
  5. Virally suppressed as defined as at least two historical viral loads \<40 copies/ml obtained between 10-18 months apart, and no intervening detectable viral load result \>= 40 copies/ml obtained during this period
  6. Most recent historical viral load result obtained within a year prior to the screening visit
  7. Willingness to undergo genetic testing

EXCLUSION CRITERIA:

1. Women who are pregnant will be excluded as the required blood draw may cause anemia and because of perturbations due to hormonal or immunosuppressive states that could impact the reservoir.
2. Inability to follow study instructions or to provide informed consent
3. Any condition deemed by the investigators to be a contraindication to study participation including active, serious infections (other than HIV infection) during the 2 weeks prior to enrollment.
4. Malignancies of any kind (e.g., Kaposi's sarcoma)
5. Therapy with systemic steroids, immunosuppressants or immunomodulating agents
6. Coagulation defects or other serious bleeding disorders
7. Current use of medications which could affect clotting.