NCT04543461From ClinicalTrials.govRecruiting

American Lung Association (ALA) Lung Health Cohort

The American Lung Association (ALA) Lung Health Cohort

Lung Diseases

At a glance

Phase: Phase not stated
Study type: Observational
Sponsor: Johns Hopkins University
Enrolment target: 4,000
Started: 29 October 2021
Main results due: 30 June 2027
Study sites: 37
Registry updated: 23 September 2026

Can you take part?

Ages 25 years to 35 years.
Open to any sex.
Healthy volunteers can take part.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria

Inclusion Criteria:

1- Age 25-35 years at the time of the baseline examination 2- Able to read and understand English or Spanish 3 -Has a social security number 4- Resident (citizen or non-citizen) of the United States (US) for at least 12 months prior to examination. Note: Individuals who are residents of the US who have temporarily spent time living outside of the US during the last 12 months (e.g., student exchange program, military posting) are eligible for participation.

5- Willing to provide contact information for at least 2 proxies who are likely to know the whereabouts and vital status of the participant

Exclusion Criteria:

1. Severe asthma, which is defined as any of the following:

1. Current (i.e. at the time of the visit) GINA Step 4 or higher therapy (medium dose ICS/LABA or high dose ICS or add-on LAMA; Medium dose = \>250 fluticasone, propionate =100 fluticasone furoate, \>200 beclomethasone, \>400 budesonide, \>220 mometasone). We will accept low-dose ICS/LABA or medium dose ICS.

OR
2. 3 or more unscheduled healthcare visits (provider/urgent care/ER) for asthma in the past 12 months OR
3. One asthma hospitalization in the past 12 months
2. History of any chronic lung disease other than asthma including but not limited to COPD, cystic fibrosis, pulmonary fibrosis, pulmonary hypertension
3. Current pregnancy
4. History of cancer other than non-melanoma skin cancer
5. Diagnosed cardiovascular diseases (i.e., congenital heart disease, coronary heart disease)
6. Inability to comply with study procedures, including

1. Inability or unwillingness to provide informed consent
2. Inability to perform study measurements
3. Inability to be contacted by phone (via calls and/or text messaging) or email
7. Any condition in the opinion of the physician that puts the participant at risk by participating in the study (e.g., serious respiratory illness requiring antibiotics or steroids or severe fever at the time of the study visit).
8. Institutionalization

What this study is about

In the sponsor’s own words, from the registry.

The ALA-LHC is a longitudinal, multi-center cohort study that will enroll approximately 4,000 young adults between the ages of 25-35 who do not have severe lung disease. The overarching objective of the ALA-LHC is to establish a national cohort of young adults for the purpose of defining lung health and developing targets to intercept chronic lung disease at its earliest stages.

Study sites(37)

University Of Alabama
Birmingham, Alabama, United States
Recruiting
University of Arizona-Tuscon
Tucson, Arizona, United States
Recruiting
University of California, Los Angeles
Los Angeles, California, United States
Recruiting
University of California, San Francisco
San Francisco, California, United States
Recruiting
University of Colorado
Aurora, Colorado, United States
Active, not recruiting
National Jewish Health
Denver, Colorado, United States
Recruiting
Nemours Children's Jacksonville
Jacksonville, Florida, United States
Recruiting
University of Florida, Jacksonville
Jacksonville, Florida, United States
Recruiting
University of Illinois at Chicago
Chicago, Illinois, United States
Recruiting
Northwestern University
Chicago, Illinois, United States
Recruiting
Rush Universtiy
Chicago, Illinois, United States
Recruiting
University of Chicago
Chicago, Illinois, United States
Withdrawn
St. Vincent's Health System
Indianapolis, Indiana, United States
Withdrawn
University of Iowa
Iowa City, Iowa, United States
Recruiting
University of Kansas
Kansas City, Kansas, United States
Recruiting
Johns Hopkins University
Baltimore, Maryland, United States
Recruiting
Brigham and Women's
Boston, Massachusetts, United States
Withdrawn
University of Michigan
Ann Arbor, Michigan, United States
Recruiting
Presbyterian Brooklyn Methodist Hospital
Brooklyn, New York, United States
Not yet recruiting
New York Medical College
Hawthorne, New York, United States
Recruiting
New York University
New York, New York, United States
Withdrawn
Mt. Sinai, NYC
New York, New York, United States
Recruiting
Columbia University
New York, New York, United States
Not yet recruiting
Cornell University
New York, New York, United States
Recruiting
University of Rochester
Rochester, New York, United States
Recruiting
University of North Carolina Hospital
Chapel Hill, North Carolina, United States
Suspended
Duke University
Durham, North Carolina, United States
Recruiting
Wake Forest School of Medicine
Winston-Salem, North Carolina, United States
Recruiting
Ohio State University
Columbus, Ohio, United States
Recruiting
Temple University
Philadelphia, Pennsylvania, United States
Recruiting
University of Pittsburg-Emphysema/COPD Research Center
Pittsburgh, Pennsylvania, United States
Recruiting
Medical University of South Carolina
Charleston, South Carolina, United States
Recruiting
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Recruiting
Baylor College of Medicine
Houston, Texas, United States
Recruiting
University of Vermont
Colchester, Vermont, United States
Recruiting
University of Washington
Seattle, Washington, United States
Not yet recruiting
University of Wisconsin Madison
Madison, Wisconsin, United States
Withdrawn

Showing 37 of 37 sites. 27 of the 37 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT04543461. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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