Unruptured Cerebral Aneurysm: Prediction of Evolution
- Unruptured Intracranial Aneurysm
At a glance
- Phase
- Phase not stated
- Study type
- Observational
- Sponsor
- Nantes University Hospital
- Enrolment target
- 1,000
- Started
- 19 August 2019
- Main results due
- 15 March 2031
- Study sites
- 29
- Registry updated
- 25 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria : * Subject carrying unruptured, asymptomatic and untreated typical IA of bifurcation, measured on conventional imaging (MRI, CTA or DSA) between 3 and 7 mm of larger diameter. * Ability to be followed-up during 3 years decided in consensus multidisciplinary gathering. * Age \> 18 years old. Exclusion Criteria : * A failure to obtain informed consent * Contraindications for undergoing an MRI scan include : (heart pacemaker, a metallic foreign body (metal sliver) in their eye, or aneurysm clip in their brain, severe claustrophobia) * Contraindications for a gadolinium contrast medium injection (:eGFR below 30 mL/min/1.73 m2, Previous or pre-existing nephrogenic systemic fibrosis, Previous anaphylactic/anaphylactoid reaction to gadolinium containing contrast agent, Acutely deteriorating renal function, Pregnancy and breast-feeding) * A mycotic, fusiform-shaped, or dissecting IA, an IA in relation with an arteriovenous malformation * A family history of polycystic kidney disease, Ehlers-Danlos syndrome, Marfan's syndrom, fibromuscular dysplasia, or Moya Moya disease * Intra-cavernous UIA because the sinus cavernous that is fulfilled with venous blood precluded a reliable assessment of aneurysmal wall enhancement (AWE)
What this study is about
In the sponsor’s own words, from the registry.
The protocol has many assets. A prospective nationwide recruitment allows for the inclusion of a large cohort of patients with UIA. It will combine accurate clinical phenotyping and comprehensive imaging with CAWE screening. Besides, it will enable to exploit metadata and to explore new pathophysiological pathways of interest by crossing clinical, genetic, biological, and imaging information.
Study sites(29)
Clairval's Hospital
Marseille, Bouches-du-Rhône, France
Recruiting
Brest University Hospital
Brest, Finistère, France
Recruiting
Bordeaux University Hospital
Bordeaux, Gironde, France
Recruiting
Toulouse University Hospital
Toulouse, Haute-Garonne, France
Recruiting
Limoges University Hospital
Limoges, Haute-Vienne, France
Recruiting
Rennes University Hospital
Rennes, Ille-et-Vilaine, France
Recruiting
Tours University Hospital
Tours, Indre-et-Loire, France
Recruiting
Nantes University Hospital
Nantes, Loire-Atlantique, France
Recruiting
Angers University Hospital
Angers, Maine et Loire, France
Recruiting
Reims University Hospital
Reims, Marne, France
Withdrawn
Nancy University Hospital
Nancy, Meurthe-et-Moselle, France
Recruiting
AP-HP La Pitié-Salpêtrière Hospital
Paris, Paris, France
Recruiting
AP-HP Le Kremlin Bicêtre Hospital
Paris, Paris, France
Recruiting
Rostchild Foundation Hospital
Paris, Paris, France
Recruiting
Rouen University Hospital
Rouen, Seine-Maritime, France
Recruiting
Amiens University Hospital
Amiens, Somme, France
Recruiting
CHU de Besançon
Besançon, France
Recruiting
CHU de Caen
Caen, France
Recruiting
CHU de Clermont Ferrand
Clermont-Ferrand, France
Recruiting
Hôpitaux Civils de Colmar
Colmar, France
Not yet recruiting
CHU Dijon
Dijon, France
Recruiting
CHU de Poitiers
Poitiers, France
Recruiting
CHU de saint Etienne
Saint-Etienne, France
Recruiting
CHU de Strasbourg
Strasbourg, France
Recruiting
Hôpital Foch
Suresnes, France
Recruiting
St Anne HIA
Toulon, France
Recruiting
Ste Anne's Hospital
Paris, Île-de-France Region, France
Recruiting
UMC Utrecht
Utrecht, Netherlands
Completed
InselHospital Bern
Bern, Switzerland
Not yet recruiting
Showing 29 of 29 sites. 25 of the 29 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT04578808. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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