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NCT05457725From ClinicalTrials.govRecruiting

Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging

Characterizing and Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging II

  • Aging
  • Cognitive Change
  • Neurocognitive Disorders, Mild

At a glance

Phase
Phase not stated
Study type
Interventional
Sponsor
University of Florida
Enrolment target
68
Started
8 October 2024
Main results due
30 April 2027
Study sites
1
Registry updated
23 September 2026

Can you take part?

  • Ages 18 years to 100 years.
  • Open to any sex.
  • You need the condition being studied — healthy volunteers are not accepted.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria
Inclusion Criteria:

* Able to provide verbal and written informed consent
* Fluent English speaker
* At least 8th grade education
* On stable medication regimen

Exclusion Criteria:

* Pregnancy
* Magnetic resonance imaging contraindications (e.g., certain metallic objects in body, claustrophobia)
* Current major depression defined as scores \>14 on the Beck Depression Inventory-II
* Impaired scores on the Telephone Interview for Cognitive Status (TICS; cut-off of \>30)
* Current use of medications with significant anticholinergic properties due to potential influence on memory ("memory enhancing"; e.g., Aricept or Namenda)
* Current use of anticonvulsant, neuroleptic, sedatives, or other medications known to affect cognition
* Uncorrected visual and hearing impairments
* Neurologic conditions affecting the brain (e.g., severe stroke, epilepsy, traumatic brain injury with \>30-minute loss of consciousness)
* Impaired scores on a cognitive screening measure, the Montreal Cognitive Assessment (MoCA); for older adults the cutoff will be age and education corrected
* Unstable medical illness (e.g., metastatic cancer)
* Significant cardiovascular conditions (e.g., major heart attack)
* Will not exclude participants who are taking anti-depressant medications. Use of antidepressants (particularly SSRI's) and anxiolytic medications will be recorded and included in post-hoc analyses

What this study is about

In the sponsor’s own words, from the registry.

Much of human interaction is based on trust. Aging has been associated with deficits in trust-related decision making, likely further exacerbated in age-associated neurodegenerative disease (Alzheimer's disease/AD), possibly underlying the dramatically growing public health problem of elder fraud. Optimal trust-related decision making and avoiding exploitation require the ability to learn about the trustworthiness of social partners across multiple interactions, but the role that learning plays in determining age deficits in trust decisions is currently unknown.

Aim: Probe the malleability of the underlying neurocircuitry of trust-learning deficits in aging. This study will utilize real-time fMRI neurofeedback to train older adults in brain activity up-regulation toward enhanced trust-related learning in aging and confirm critical mechanisms of experience-dependent social decisions in aging.

Grant R01AG072658 Aim 3: Test the malleability of trust-learning neurocircuitry toward optimized trust-related decision making in aging.

Study sites(1)

  • University of Florida

    Gainesville, Florida, United States

    Recruiting

Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT05457725. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging | Trialion