Benefits of Nicotinamide Riboside Upon Cognition and Sleep
The Benefits of Nicotinamide Riboside Upon Cognition and Sleep in Older Veterans
- Cognitive Impairment
- Sleep Quality
At a glance
- Phase
- Phase not stated
- Study type
- Interventional
- Sponsor
- State University of New York at Buffalo
- Enrolment target
- 50
- Started
- 4 April 2023
- Main results due
- 30 August 2027
- Study sites
- 3
- Registry updated
- 24 September 2026
Can you take part?
- Ages 65 years to 85 years.
- Open to any sex.
- Healthy volunteers can take part.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Sleep Quality. Pittsburgh Sleep Quality Index (PSQI) global score \>5 Exclusion Criteria: * Dementia. Veteran Affairs - St. Louis University Mental Status questionnaire (VA-SLUMS) score \<20
What this study is about
In the sponsor’s own words, from the registry.
Poor sleep quality and short sleep duration may be a mechanistic component of cognitive impairment in older adults, associated with a decline in brain-derived neurotrophic factor. Increasing the availability of nicotinamide adenine dinucleotide (NAD+) with supplementation of its precursor, nicotinamide riboside (NR), a form of vitamin B3 may increase the expression of brain-derived neurotrophic factor. This study proposes to examine the benefits of NR supplementation on sleep and cognitive function in older adults with comprehensive subjective and objective measures and to explore its impacts on serum brain-derived neurotrophic factor.
Study sites(3)
State University of New York at Buffalo
Buffalo, New York, United States
Not yet recruiting
University at Buffalo State University of New York
Buffalo, New York, United States
Not yet recruiting
Buffalo Veteran Affairs Medical Center
Buffalo, New York, United States
Recruiting
Showing 3 of 3 sites. 1 of the 3 sites on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT05500170. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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