A2 to O Lung Transplants
Blood Group A2 Donor to Blood Group O Recipient Lung Transplantation
- Lung Transplant
- ABO Incompatibility
At a glance
- Phase
- Phase not stated
- Study type
- Interventional
- Sponsor
- University Health Network, Toronto
- Enrolment target
- 10
- Started
- 14 July 2022
- Main results due
- 31 December 2027
- Study sites
- 1
- Registry updated
- 29 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * first lung transplant * blood group O recipient * low pre-operative anti-A antibody titers * consent to study participation Exclusion Criteria: * re-transplant * multiorgan transplant * positive virtual crossmatch at time of transplant
What this study is about
In the sponsor’s own words, from the registry.
Blood group A2 to blood group O kidney and liver transplants have been shown to be safe and successful, especially in recipients with low pre-operative anti-A antibody titers and with the use of peri-operative antibody-depleting therapies. Since blood group O lung transplant candidates tend to have longer wait times and a higher waitlist mortality compared to other blood groups, we propose to conduct a prospective study of lung transplantation from blood group A2 donors to eligible blood group O recipients in an effort to increase the available donor pool. The aim of this study is to determine both the feasibility and safety of this specific type of ABO-incompatible lung transplant, and the impact of this practice on reducing transplant wait times among blood group O lung transplant candidates. This would represent the first prospective study of ABO-incompatible lung transplants worldwide.
Study sites(1)
Toronto General Hospital, University Health Network
Toronto, Ontario, Canada
Recruiting
Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT05581745. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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