Blood Pressure Variability and Ischemic Stroke Outcome
- Acute Ischemic Stroke
- Blood Pressure Variability
At a glance
- Phase
- Phase not stated
- Study type
- Observational
- Sponsor
- Yale University
- Enrolment target
- 150
- Started
- 15 July 2024
- Main results due
- 15 July 2027
- Study sites
- 3
- Registry updated
- 28 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria:
* Ischemic stroke according to the American Heart Association (AHA) definition and either:
1. CT or MRI showing ischemic stroke in the anterior circulation (frontal, parietal or superior temporal lobes), or
2. Occlusion of the internal carotid, middle cerebral or anterior cerebral arteries on computed tomography angiography (CTA) or magnetic resonance angiography (MRA)
Onset of ischemic stroke within 48 hours and able to get baseline pMRI within 72 hours of arrival
4\) NIH Stroke Scale ≥ 4 at time of enrollment
Exclusion Criteria:
* Pre-morbid mRS ≥3
* Predicted hospital system admission \<72 hours
* Pacemaker or other MRI contraindications per American College of Radiology guidelinesWhat this study is about
In the sponsor’s own words, from the registry.
The goal of this observational study is to evaluate the role of blood pressure (BPV) variability in patients suffering from acute ischemic stroke. The main questions it aims to answer are:
1. To determine the association of BPV with functional/cognitive outcome after ischemic stroke. 2. To determine a pathophysiologic mechanism of BPV's deleterious effect on functional outcome. 3. To evaluate potential treatment targets to pharmacologically reduce BPV after ischemic stroke.
Study sites(3)
Yale-New Haven Hospital
New Haven, Connecticut, United States
Recruiting
University of Chicago Medical Center
Chicago, Illinois, United States
Recruiting
Massachusetts General Hospital
Boston, Massachusetts, United States
Recruiting
Showing 3 of 3 sites. 3 of the 3 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT05756257. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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