NCT06465810From ClinicalTrials.govRecruiting

Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis

A Non-interventional, Prospective, Multi-country Study Collecting Real-world Data on the Characteristics, Treatment Patterns, and Outcomes of Patients With Transthyretin (ATTR) Amyloidosis

Transthyretin Amyloidosis
ATTR-CM
ATTRv-PN
ATTR
ATTR-Mixed
hATTR

At a glance

Phase: Phase not stated
Study type: Observational
Sponsor: AstraZeneca
Enrolment target: 1,850
Started: 25 June 2024
Main results due: 31 December 2031
Study sites: 89
Registry updated: 23 September 2026

Can you take part?

Ages 18 years to 130 years.
Open to any sex.
You need the condition being studied — healthy volunteers are not accepted.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria

Inclusion Criteria:

* Patient willing and able to provide written informed consent to participate in the study
* Confirmed diagnosis of amyloid transthyretin (ATTR) amyloidosis
* Aged ≥18 years at the time of signing the informed consent
* Patient willing and able to participate in collection of electronic patient reported outcomes (PROs)

Exclusion Criteria:

* Concurrent participation in any interventional trial for ATTR amyloidosis
* Involvement in the planning and/or conduct of the current study
* Patients with evidence of primary or light chain amyloidosis (AL) or serum protein A amyloidosis (AA)
* Asymptomatic patients with ATTR amyloidosis and asymptomatic ATTR mutation carriers

What this study is about

In the sponsor’s own words, from the registry.

The MaesTTRo study aims to enroll a global cohort of patients with transthyretin (ATTR) amyloidosis to longitudinally observe the natural course of the disease and describe real-world treatment patterns and outcomes. In addition, information on the effectiveness of ATTR amyloidosis treatments, including eplontersen, which is a ligand-conjugated antisense oligonucleotide gene silencing treatment targeting activity against both the mutant and wild-type TTR protein, will be collected.

Study sites(89)

Research Site
La Jolla, California, United States
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Los Angeles, California, United States
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San Francisco, California, United States
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San Francisco, California, United States
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New Haven, Connecticut, United States
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Washington D.C., District of Columbia, United States
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Chicago, Illinois, United States
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Indianapolis, Indiana, United States
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Baltimore, Maryland, United States
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Boston, Massachusetts, United States
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Boston, Massachusetts, United States
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Boston, Massachusetts, United States
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Rochester, Minnesota, United States
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Kansas City, Missouri, United States
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St Louis, Missouri, United States
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New Brunswick, New Jersey, United States
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Manhasset, New York, United States
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New York, New York, United States
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New York, New York, United States
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New York, New York, United States
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Durham, North Carolina, United States
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Portland, Oregon, United States
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Danville, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Greenville, South Carolina, United States
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Germantown, Tennessee, United States
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Nashville, Tennessee, United States
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Dallas, Texas, United States
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Houston, Texas, United States
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Richmond, Virginia, United States
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Seattle, Washington, United States
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Milwaukee, Wisconsin, United States
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Vancouver, British Columbia, Canada
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Vancouver, British Columbia, Canada
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Halifax, Nova Scotia, Canada
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London, Ontario, Canada
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Toronto, Ontario, Canada
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Montreal, Quebec, Canada
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Rimouski, Quebec, Canada
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Hefei, Anhui, China
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Beijing, Beijing Municipality, China
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Beijing, Beijing Municipality, China
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Beijing, Beijing Municipality, China
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Beijing, Beijing Municipality, China
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Chongqing, Chongqing Municipality, China
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Fuzhou, Fujian, China
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Xiamen, Fujian, China
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Guangzhou, Guangdong, China
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Guangzhou, Guangdong, China
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Guiyang, Guizhou, China
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Shijiazhuang, Hebei, China
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Wuhan, Hubei, China
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Wuhan, Hubei, China
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Changsha, Hunan, China
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Changsha, Hunan, China
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Nanjing, Jiangsu, China
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Suzhou, Jiangsu, China
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Nanchang, Jiangxi, China
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Dalian, Liaoning, China
Not yet recruiting

Showing 60 of 89 sites — filter to narrow it down. 73 of the 89 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT06465810. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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