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NCT06471751From ClinicalTrials.govRecruiting

Strengthening Inspiratory and Oropharyngeal Muscles in Moderate Obstructive Sleep Apnea Hypopnea Syndrome

  • Obstructive Sleep Apnea

At a glance

Phase
Phase not stated
Study type
Interventional
Sponsor
Centre Hospitalier Universitaire de Saint Etienne
Enrolment target
38
Started
30 December 2024
Main results due
1 August 2027
Study sites
2
Registry updated
25 September 2026

Can you take part?

  • Aged 18 years and over.
  • Open to any sex.
  • You need the condition being studied — healthy volunteers are not accepted.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria
Inclusion Criteria:

* Moderate SAHOS (15 ≤ AHI ≤30);
* Body Mass Index (BMI) \< 35 ;
* Patient affiliated or entitled to a social security scheme;
* Patient having signed a consent to participate in the study.

Exclusion Criteria:

* Excessive daytime sleepiness: Epworth sleepiness score \> 10 ;
* Professional driving and history of accidents related to sleepiness;
* Severe obstructive or restrictive ventilatory disorders of neuromuscular origin authenticated by respiratory function tests;
* Patients undergoing treatment for OSAS or requiring immediate initiation of continuous positive airway pressure (CPAP) or a mandibular advancement orthosis;
* Patients who have stopped CPAP or orthosis treatment in less than one month;
* Patients undergoing cardiorespiratory exercise rehabilitation or starting regular physical training;
* Uncompensated heart failure, thoracic sternotomy surgery \< 4 months;
* Marked osteoporosis with history of rib fractures;
* History of spontaneous pneumothorax;
* Severe asthma;
* Perforated eardrum or any other ear condition;
* Pulmonary hypertension;
* History of pharyngeal surgery to treat sleep apnea;
* Pregnant women or women in labor;
* Individuals deprived of their liberty or hospitalized without consent;
* Adults subject to legal protective measures (guardianship or conservatorship).

Contraindications for MRI

* Patient with claustrophobia;
* Patient for whom MRI is contraindicated (pacemaker, metallic heart valve, metallic foreign body in the eye).

What this study is about

In the sponsor’s own words, from the registry.

The Obstructive Sleep Apnea hypopnea Syndrome (OSAS), whose prevalence is 4% of the French population, can lead to serious health consequences (risk of road accidents, onset of cardiovascular disease, etc.). OSAS corresponds to a certain number of interruptions (apneas) or reductions (hypopneas) of ventilation during sleep. The weakening of the tone of the inspiratory and oropharyngeal muscles is one of the main causes of upper airways obstruction during the inspiratory phase.

Study sites(2)

  • CHU de Grenoble

    Grenoble, France

    Not yet recruiting

  • Centre Hospitalier Universitaire

    Saint-Etienne, France

    Recruiting

Showing 2 of 2 sites. 1 of the 2 sites on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT06471751. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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Strengthening Inspiratory and Oropharyngeal Muscles in Moderate Obstructive Sleep Apnea Hypopnea Syndrome | Trialion