Study Brain Mechanisms of Frustration With Magnetoencephalography in Healthy Volunteers

-INCLUSION CRITERIA:

This study will include adult healthy volunteers.

* Age: 18-55
* Consent: can give consent
* Speak and read English

  --The instruments have not been validated in other languages.
* At the NIH site, previously screened through other NIH protocols such as protocol 01-M-0254, 17-M-0181, and 93-M-0170 and determined eligible as healthy volunteers.

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this

study:

-Any serious medical condition

* History, physical exam, or laboratory testing including drug abuse screen.

  -Prescription and over-the-counter medications and dietary supplements with psychoactive properties (e.g., St. John's Wort, Melatonin, Valerian)

  -Any condition that interferes with MRI or MEG\*\*
* History

  -Any current psychiatric diagnosis
* SCID-V, clinical assessment, or history.

  -Pregnancy
* Pregnancy testing will be done before all MRIs.

  -People who work on night shifts
* History

  -Drug use
* Subjects with drug use or positive drug screen more than two years ago are eligible for participation.

  -Need to wear eye glasses to work with computers\*
* History

  -Need to wear contact lenses to work with computers\*\*,\*\*\*
* History

  -Dental retainer\*\*
* Subjects wearing removable dental retainers are eligible for participation

  * Eye glasses create artifacts in MEG and their rigid shape does not fit well in the MEG scanner. The MEG core has plastic optometry lenses that can be placed in paper frames. However, the paper frames need to be secured with tape which makes wearing them very uncomfortable, potentially promoting negative emotion and reducing the reliability of facial expression analysis.

    * Only applies to the NIH site.

      * Contact lenses create artifacts that interfere with eye-tracking.