International CRDS Registry
International Calcium Release Deficiency Syndrome Registry
- Calcium Release Deficiency Syndrome
At a glance
- Phase
- Phase not stated
- Study type
- Observational
- Sponsor
- Population Health Research Institute
- Enrolment target
- 500
- Started
- 21 November 2024
- Main results due
- 31 December 2050
- Study sites
- 22
- Registry updated
- 28 September 2026
Can you take part?
- No age limit is stated.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
CRDS Cohort Inclusion Criterion: \- Presence of a rare\* RYR2 variant that is characterized to be loss-of-function based on in vitro testing# RYR2 Truncating and Large CNV Cohort Inclusion Criterion: \- Presence of a rare\* RYR2 truncating variant and/or large copy number variant involving the RYR2 gene. Carriers of a Non-Functional RYR2 variant Inclusion Criterion: \- Presence of a rare\* RYR2 variant that is characterized to be neither loss- nor gain-of-function based on in vitro testing# \*rare defined as gnomAD prevalence \< 0.1% #RYR2 in vitro functional testing will be performed in the laboratory of Dr. Wayne Chen (University of Calgary)
What this study is about
In the sponsor’s own words, from the registry.
Calcium Release Deficiency Syndrome (CRDS) is a newly discovered genetic arrhythmia syndrome that confers a risk of life-threatening arrhythmias secondary to RYR2 loss-of-function. The International CRDS registry has been designed to facilitate large-scale evaluation of CRDS, including its phenotypic spectrum, approaches to risk stratification, and optimal treatment strategies.
Study sites(22)
University of California
San Francisco, California, United States
Recruiting
Mayo Clinic
Rochester, Minnesota, United States
Recruiting
Duke University
Durham, North Carolina, United States
Recruiting
Inova Health Care Services
Fairfax, Virginia, United States
Recruiting
Garvan Institute of Medical Research
Darlinghurst, New South Wales, Australia
Recruiting
Antwerp University Hospital
Edegem, Antwerp, Belgium
Recruiting
Universitair Ziekenhuis Brussel
Brussels, Belgium
Recruiting
University of Calgary
Calgary, Alberta, Canada
Recruiting
Alberta Health Services
Edmonton, Alberta, Canada
Recruiting
Children's & Women's Health Centre of British Columbia
Vancouver, British Columbia, Canada
Recruiting
The University of British Columbia
Vancouver, British Columbia, Canada
Recruiting
Hamilton General Hospital
Hamilton, Ontario, Canada
Recruiting
London Health Sciences Centre - University Hospital
London, Ontario, Canada
Recruiting
Ottawa Heart Institute
Ottawa, Ontario, Canada
Recruiting
Montréal Heart Institute
Montreal, Quebec, Canada
Recruiting
Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval
Québec, Quebec, Canada
Recruiting
Rigshospitalet
Copenhagen, The Capital Region of Denmark, Denmark
Recruiting
Aarhus University Hospital
Aarhus, Denmark
Recruiting
CHU de Bordeaux
Bordeaux, New Aquitaine, France
Recruiting
Shaare Zedek Medical Center
Jerusalem, Israel
Recruiting
Oxford University Hospitals
Oxford, Oxfordshire, United Kingdom
Recruiting
City St George's, University of London
London, United Kingdom
Recruiting
Showing 22 of 22 sites. 22 of the 22 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT06508164. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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