NCT06626022From ClinicalTrials.govRecruiting

Screening for Prostate Cancer Using High Resolution Micro-ultrasound Versus Multiparametric Magnetic Resonance Imaging.

A Phase 3, Multicenter, International, Non-inferiority, Randomized Clinical Trial Comparing Screening for Prostate Cancer Using High Resolution Micro-ultrasound Versus Multiparametric Magnetic Resonance Imaging (MUSIC-Screen)

Prostate Cancer Screening

At a glance

Phase: Phase 3
Study type: Interventional
Sponsor: University of Alberta
Enrolment target: 1,284
Started: 8 May 2025
Main results due: 30 November 2029
Study sites: 9
Registry updated: 25 September 2026

Can you take part?

Ages 50 years to 70 years.
Men only.
Healthy volunteers can take part.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria

Inclusion Criteria:

1. Male sex;
2. Age 50-70;
3. PSA 3-20 and/or abnormal DRE;
4. Biopsy naïve.

Exclusion Criteria:

1. Prior personal history of prostate cancer;
2. Prior prostate imaging using microUS or MRI;
3. Contraindication to microUS or MRI;
4. Testosterone replacement therapy within last 12 months; or
5. Androgen deprivation therapy within last 12 months.

What this study is about

In the sponsor’s own words, from the registry.

The purpose of this study is to compare whether the FDA and Health Canada approved microUS is as effective as the currently used option (MRI) for imaging the prostate gland. Participants will be randomized into two groups to compare the imaging results of the current standard of care MRI and the new microUS. The study is looking to identify the most effective imaging modality to help guide whether you progress to have a prostate biopsy.

Study sites(9)

University of California, Los Angeles (UCLA)
Los Angeles, California, United States
Recruiting
UT Southwestern Medical Center
Dallas, Texas, United States
Not yet recruiting
University of Alberta
Edmonton, Alberta, Canada
Active, not recruiting
University of British Columbia
Vancouver, British Columbia, Canada
Recruiting
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada
Recruiting
CIUSSS du Nord-de-l'Île-de-Montréal
Montréal, Quebec, Canada
Not yet recruiting
CH de Martigues
Martigues, France
Recruiting
Vestfold Hospital Trust
Tønsberg, Norway
Recruiting
Urologia Clinica Bilbao
Bilbao, Spain
Recruiting

Showing 9 of 9 sites. 6 of the 9 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT06626022. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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