Surveillance of Pancreatic Health After Diabetes Diagnosis
An Interventional Study to Evaluate the cfDNA Pancreatic Cancer Test (Avantect) in the Early Detection of Pancreatic Cancer in Participants With Newly Diagnosed Diabetes Mellitus or Newly Elevated HbA1c
- Diabetes Mellitus
- Pancreatic Cancer, Adult
At a glance
- Phase
- Phase not stated
- Study type
- Interventional
- Sponsor
- University Hospital Southampton NHS Foundation Trust
- Enrolment target
- 5,000
- Started
- 21 May 2025
- Main results due
- 29 July 2029
- Study sites
- 31
- Registry updated
- 28 September 2026
Can you take part?
- Ages 50 years to 84 years.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * 50 - 84 years of age at the time of enrolment (within year of birth, not month of birth) * Confirmed type 2 DM diagnosis established within the last 200 days or an initial elevated HbA1c ≥ 48 mmol/mol or 6.5% obtained within the last 200 days. This includes people who have a first elevated HbA1c (≥ 48 mmol/mol or 6.5%) within the last 200 days, even if subsequent HbAc1 measurements return to the the normal range. * Willing to provide up to 30 mL of blood for each study visit * Willing and eligible to undergo MRI or CT scan * Understands the study process and is willing to take part in the study and sign the informed consent form Exclusion Criteria: * Prior type I or type II DM diagnosis or an initial HbA1c ≥ 48 mmol/mol or 6.5% obtained prior to the 200-day inclusion window, except gestational elevated HbA1c. * A history of pancreatic cancer, pancreatic neuroendocrine tumour (pNET) or Pancreatitis * Under investigation for or confirmed pancreatic cancer * Under investigation/surveillance for pancreatic cyst * Any known pancreatic surgery (not including ERCP), or other major surgery requiring anaesthesia within 3 months * Any invasive solid or haematological cancer in the past 3 years, including cancer recurrence after treatment in the last 3 years * BMI \> 40 at the time of consent * Blood transfusion within 1 month * Solid organ transplant recipient * Currently pregnant * Needing dialysis
What this study is about
In the sponsor’s own words, from the registry.
The goal of this interventional study is to evaluate if the novel diagnostic blood test, called Avantect can early detect pancreatic cancer in patients diagnosed with type 2 diabetes or with elevated sugar levels within the last 200 days.
Participants will:
* attend 3 study visits over 12 months time * provide a blood sample at each study visit * complete an anxiety questionnaire at each visit.
Study sites(31)
Ashfields Primary Care Centre
Sandbach, Cheshire, United Kingdom
Active, not recruiting
Maidstone and Tunbridge Wells NHS Trust
Maidstone, Kent, United Kingdom
Recruiting
Forest Medical Group
Leicester, Leicester Forest East, United Kingdom
Recruiting
South Leicestershire Medical Group
Kibworth Beauchamp, Leicestershire, United Kingdom
Recruiting
Peel Croft Surgery
Burton-on-Trent, Staffordshire, United Kingdom
Recruiting
Kingswinford Medical Practice
Kingswinford, Staffordshire, United Kingdom
Recruiting
Park Medical Centre
Leek, Staffordshire, United Kingdom
Recruiting
Trinity Court Surgery
Stratford-upon-Avon, Staffordshire, United Kingdom
Recruiting
Brockwood Medical Practice
Brockham, Surrey, United Kingdom
Recruiting
Integrated Care Partnership/ The Old Cottage Hospital
Epsom, Surrey, United Kingdom
Recruiting
Warlingham Green Medical Practice
Warlingham, Surrey, United Kingdom
Recruiting
Ashton Medical Group
Ashton-under-Lyne, United Kingdom
Active, not recruiting
Yardley Wood Health Centre
Birmingham, United Kingdom
Recruiting
Bournemouth Research Hub
Bournemouth, United Kingdom
Active, not recruiting
Eastham Group Practice
Bromborough, United Kingdom
Recruiting
Willesden Medical Centre
London, United Kingdom
Recruiting
South Westminster Centre
London, United Kingdom
Recruiting
The Cuckoo Lane Practice
London, United Kingdom
Recruiting
Bodey Medical Centre
Manchester, United Kingdom
Active, not recruiting
Bowland Medical Practice
Manchester, United Kingdom
Active, not recruiting
The Maples Medical Centre
Manchester, United Kingdom
Active, not recruiting
King's Mill Hospital (Sherwood Forest) Research Van
Nottingham, United Kingdom
Recruiting
Portsmouth Research Hub
Portsmouth, United Kingdom
Active, not recruiting
Hazelvalley Family Practice
Rossendale, United Kingdom
Recruiting
Pembroke Centre (Hillingdon)
Ruislip, United Kingdom
Recruiting
Southampton Research Hub (Shirley Research Hub)
Southampton, United Kingdom
Active, not recruiting
Moorgreen Hospital
Southampton, United Kingdom
Recruiting
Balance Street Health Centre
Uttoxeter, United Kingdom
Recruiting
Civic Centre
Uxbridge, United Kingdom
Recruiting
Quinton Practice
Walsall, United Kingdom
Recruiting
Weymouth Research Hub
Weymouth, United Kingdom
Active, not recruiting
Showing 31 of 31 sites. 22 of the 31 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT06803771. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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