Canadian Consortium on Airway Mucus Occlusions in Asthma, COPD and Chronic Cough
Canadian Consortium for Understanding the Role of Airway Mucus Occlusions in Asthma, COPD and Chronic Cough
- Asthma
- Chronic Obstructive Pulmonary Disease (COPD)
- Chronic Cough (CC)
At a glance
- Phase
- Phase not stated
- Study type
- Observational
- Sponsor
- McMaster University
- Enrolment target
- 240
- Started
- 11 December 2025
- Main results due
- December 2027
- Study sites
- 7
- Registry updated
- 24 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- Healthy volunteers can take part.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Males and females (≥18 years old) Asthma: Respiratory physician confirmed diagnosis of moderate-to-severe asthma and Historical objective evidence of asthma and/or specialist/respirologist confirmation (post-bronchodilator reversibility and/or methacholine bronchoprovocation test \<8 mg/mL) COPD: Respiratory physician confirmed diagnosis of COPD that is moderate-to-severe according to GOLD criteria (post-bronchodilator FEV1/FVC\<LLN and FEV1\< 80%pred) and CAT score ≥10 or mMRC score ≥ 2 Chronic cough: Refractory Chronic Cough (RCC) and Unexplained Chronic Cough (UCC) lasting \>1 year with Normal chest radiograph and no airflow obstruction (FEV1/FVC \>Lower Limit of Normal) Healthy participants: No history of respiratory disease or other pulmonary disorders and no use of inhaled medications or corticosteroids with normal spirometry and Modified Medical Research Council (mMRC) Dyspnea Scale =\<1 Exclusion Criteria: * Pregnant or breastfeeding * Current smoker or \>10 yr pack history or smoked within the last 6 months * Exacerbation within 4 weeks of recruitment * Preterm birth (≤36 weeks gestation) or perinatal complications * History of other pulmonary disorders * Specialist/Respirologist suspects primary ciliary dyskinesia (PCD) * Current use of mucolytic medications * Memory, cognitive, or psychiatric limitations that may prevent optimal participation * Treatment with current biologic therapy: anti-IgE mAb within 130 days, anti-IL-4/4R, IL-5/5R, IL-13, or TSLP within 2 months or 5 half-lives whichever is longer prior to visit 1
What this study is about
In the sponsor’s own words, from the registry.
Chronic lung diseases affect one in five Canadians, causing symptoms such as cough, breathlessness, and wheeze. Despite advancements in medical care, these conditions not only impact individuals and their close circles but also present substantial clinical and economic challenges at a national level. This grant is dedicated to addressing three prevalent lung diseases: asthma, chronic obstructive pulmonary disease (COPD), and chronic cough. An alliance of clinicians, scientists, knowledge users, and patient partners from across Canada have come together to establish the Canadian Consortium for Understanding the Role of Airway Mucus Occlusions in Asthma, COPD, and Chronic Cough - "CANMuc." Mucus plays a pivotal role in the symptoms and severity of lung diseases, but its clinical assessment has been challenging. Fortunately, recent medical advances, particularly chest computed tomography (CT), facilitate visualizing and quantifying mucus in patients with lung diseases. Our goal is to initially assess mucus plugging in a diverse group of Canadians without lung disease and then compare these findings to those with asthma, COPD, and chronic cough. The investigators will recruit 100 healthy volunteers for comprehensive clinical and research evaluations, including sputum analyses, breathing tests, quality of life assessments, cough monitoring, and CT scans. In addition, testing will be conducted twice, two years apart, in 240 adult and 50 pediatric participants. This approach will enable the investigators to understand the burden of mucus and how it changes over time, explore proteins or chemicals in mucus that predict mucus persistence, and identify biomarkers that can help guide physicians to prescribe targeted treatments that might work better than others. The CANMuc team's findings will guide strategies for identifying and treating mucus plugging, inform policymakers, and share knowledge with Canadians living with asthma, COPD, and chronic cough.
Study sites(7)
St. Paul's Hospital
Vancouver, British Columbia, Canada
Not yet recruiting
St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada
Recruiting
Robarts Research Institute
London, Ontario, Canada
Not yet recruiting
The Ottawa Hospital
Ottawa, Ontario, Canada
Not yet recruiting
McGill University Health Centre
Montreal, Quebec, Canada
Not yet recruiting
Quebec Heart and Lung Institute - Laval University
Québec, Quebec, Canada
Not yet recruiting
Université de Sherbrooke
Sherbrooke, Quebec, Canada
Not yet recruiting
Showing 7 of 7 sites. 1 of the 7 sites on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT06858748. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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