Deciphering the Genetic Architecture of Autoimmune Diseases
- Autoimmune Diseases
At a glance
- Phase
- Phase not stated
- Study type
- Observational
- Sponsor
- National Human Genome Research Institute (NHGRI)
- Enrolment target
- 300
- Started
- 4 October 2026
- Main results due
- 22 April 2030
- Study sites
- 2
- Registry updated
- 29 September 2026
Can you take part?
- Ages 18 years to 115 years.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
* INCLUSION CRITERIA: Any person who meets the criteria for inclusion in the study will be considered and must have the patient's signed informed consent for participation. Autoimmune Disease Diagnosis: Cases: * Patients diagnosed with SLE, Sjogren's disease, scleroderma, rheumatoid arthritis, seronegative spondyloarthropathies, and systemic vasculitis, as defined by the American College of Rheumatology classification criteria. * Over 18 years old Controls: * Family members of identified cases, and unrelated individuals. The controls would be from the same community as the patients and families studied, and of the same age and gender. Screening for autoimmune diseases and allergic diseases will be performed. * Over 18 years old EXCLUSION CRITERIA: -People diagnosed with a chronic viral disease: HIV, hepatitis C or HTLV-1.
What this study is about
In the sponsor’s own words, from the registry.
Background:
Autoimmune diseases can be caused by genes people inherit from their parents. The gene changes that cause these diseases have been well studied in people with European and Asian ancestors. But some diseases behave differently in people who are native to North and South America. Researchers want to know more about the gene changes and other factors that may cause autoimmune diseases among these people. This project will be based in Peru.
Objective:
To study how gene changes can lead to autoimmune diseases in people native to Peru.
Eligibility:
People aged 18 years and older with an autoimmune disease. These may include systemic lupus erythematosus; Sjogren disease; scleroderma; rheumatoid arthritis; seronegative spondylo-arthropathies; and systemic vasculitis. Family members and healthy volunteers are also needed.
Design:
Participants will have 2 clinic visits; these will be 2 weeks apart. The clinics will be in Lima, Iquitos, and other sites in Peru.
Visit 1: Participants will have a physical exam. They will answer questions about their health risks and habits. They will provide blood and urine samples.
Visit 2: Participants will provide a second blood sample and a stool sample. They will talk about the results of their first clinical exam with researchers.
The cost of travel to and from the clinics will be provided. Participants will get $30 per visit and a snack.
Study sites(2)
National Human Genome Research Institute (NHGRI)
Bethesda, Maryland, United States
Completed
Amazon Rainforest
Lima, Peru
Recruiting
Showing 2 of 2 sites. 1 of the 2 sites on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT06948110. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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