A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
A Phase 2b/3, Randomized, Double-Blind Study to Investigate the Efficacy, Safety, and Tolerability of Ponsegromab (PF-06946860) Compared With Placebo Both With Background First-Line Chemotherapy in Adult Participants With Cachexia and Metastatic Pancreatic Ductal Adenocarcinoma
- Cachexia
- Metastatic Pancreatic Ductal Adenocarcinoma
At a glance
- Phase
- Phase 2
- Study type
- Interventional
- Sponsor
- Pfizer
- Enrolment target
- 982
- Started
- 3 October 2025
- Main results due
- 23 January 2028
- Study sites
- 223
- Registry updated
- 25 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Key inclusion Criteria: * Signed Informed Consent Document * Documented active diagnosis of metastatic pancreatic ductal adenocarcinoma * Cachexia defined by Fearon criteria of weight loss * Completed 1 x 28-day cycle of first-line systemic nab-paclitaxel and gemcitabine chemotherapy or 2 x 14-day cycles of FOLFIRINOX chemotherapy and prior to receiving Cycle 2 chemotherapy * ECOG PS ≤1 with life expectancy of at least 4 months Key Exclusion Criteria: * Current active reversible causes of decreased food intake * Cachexia caused by other reasons * Any prior or current clinical diagnosis of heart failure, irrespective of left ventricular ejection fraction or New York Heart Association classification * Left ventricular ejection fraction \<50% * Receiving tube feedings or parenteral nutrition at the time of Screening or Randomization * History of allergic or anaphylactic reaction to any therapeutic or diagnostic monoclonal antibody * History of allergy or hypersensitivity to any of the chemotherapeutics or any of their excipients * Neuroendocrine (carcinoid, islet cell) or acinar pancreatic carcinoma, symptomatic brain metastasis, leptomeningeal disease or other active CNS metastases * Inadequate liver function * Renal disease requiring dialysis or eGFR \<30 mL/min/1.73m2
What this study is about
In the sponsor’s own words, from the registry.
Study to investigate the efficacy, safety and tolerability of systemic chemotherapy plus ponsegromab versus systemic chemotherapy plus placebo for the first-line treatment in adult participants with cachexia and metastatic pancreatic ductal adenocardinoma.
Study sites(223)
The Kirklin Clinic of UAB Hospital
Birmingham, Alabama, United States
Recruiting
The University of Alabama at Birmingham
Birmingham, Alabama, United States
Recruiting
Mayo Clinic Hospital
Phoenix, Arizona, United States
Recruiting
Central Arkansas Radiation Therapy Institute, dba CARTI
Bryant, Arkansas, United States
Recruiting
Central Arkansas Radiation Therapy Institute, dba CARTI
Conway, Arkansas, United States
Recruiting
CARTI Cancer Center
Little Rock, Arkansas, United States
Recruiting
Central Arkansas Radiation Therapy Institute, dba CARTI
North Little Rock, Arkansas, United States
Recruiting
Central Arkansas Radiation Therapy Institute, dba CARTI
Pine Bluff, Arkansas, United States
Recruiting
UC San Diego Medical Center - Encinitas
Encinitas, California, United States
Recruiting
Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California, United States
Recruiting
UCI Health - Irvine
Irvine, California, United States
Recruiting
UC San Diego Koman Family Outpatient Pavilion
La Jolla, California, United States
Recruiting
UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion)
La Jolla, California, United States
Recruiting
UC San Diego Moores Cancer Center
La Jolla, California, United States
Recruiting
UC San Diego Sulpizio Cardiovascular Center
La Jolla, California, United States
Recruiting
Cedars-Sinai Cancer at Cedars-Sinai Medical Center
Los Angeles, California, United States
Recruiting
UCLA Department of Medicine - Hematology/Oncology
Los Angeles, California, United States
Recruiting
UC Irvine Health
Orange, California, United States
Recruiting
UC San Diego Medical Center - Bankers Hill
San Diego, California, United States
Recruiting
UC San Diego McGrath Outpatient Pavilion - Hillcrest
San Diego, California, United States
Recruiting
UC San Diego Medical Center - Hillcrest
San Diego, California, United States
Recruiting
UC San Diego Medical Center - Rancho Bernardo
San Diego, California, United States
Recruiting
UCLA Hematology/Oncology - Santa Monica
Santa Monica, California, United States
Recruiting
Providence Medical Foundation
Santa Rosa, California, United States
Recruiting
UC San Diego Medical Center - Vista
Vista, California, United States
Recruiting
Georgetown University Medical Center - Department of Pharmacy, Oncology Pharmacy
Washington D.C., District of Columbia, United States
Recruiting
Georgetown University Medical Center
Washington D.C., District of Columbia, United States
Recruiting
Mayo Clinic Pharmacy
Jacksonville, Florida, United States
Recruiting
Mayo Clinic
Jacksonville, Florida, United States
Recruiting
University Cancer & Blood Center, LLC
Athens, Georgia, United States
Recruiting
Invision, LLC
Honolulu, Hawaii, United States
Recruiting
University of Hawaii Cancer Center
Honolulu, Hawaii, United States
Recruiting
Cardiology Associates, Inc
‘Aiea, Hawaii, United States
Recruiting
Cancer Care Specialists of Illinois
Decatur, Illinois, United States
Recruiting
Decatur Memorial Hospital
Decatur, Illinois, United States
Recruiting
Hope and Healing Clinical Research LLC
Hinsdale, Illinois, United States
Recruiting
Hope and Healing Clinical Research LLC New Lenox- Research Department
New Lenox, Illinois, United States
Recruiting
Cancer Care Specialists of Illinois - Cancer Care Center of O'Fallon
O'Fallon, Illinois, United States
Recruiting
United Imaging Consultants
Lenexa, Kansas, United States
Recruiting
MidAmerica Cancer Care- American Oncology Partners
Merriam, Kansas, United States
Recruiting
University of Kentucky Research Foundation
Lexington, Kentucky, United States
Recruiting
University of Kentucky Healthcare - Markey Cancer Center
Lexington, Kentucky, United States
Recruiting
University of Kentucky Medical Center
Lexington, Kentucky, United States
Recruiting
University of Kentucky, Markey Cancer Center Clinical Research Office (UK MCC CRO)
Lexington, Kentucky, United States
Recruiting
JHU Oncology Central Kit Services
Baltimore, Maryland, United States
Recruiting
Johns Hopkins Hospital
Baltimore, Maryland, United States
Recruiting
Oncology Investigational Drug Service (IDS)
Baltimore, Maryland, United States
Recruiting
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, United States
Recruiting
Mayo Clinic Cancer Center Outpatient Pharmacy
Rochester, Minnesota, United States
Recruiting
Mayo Clinic
Rochester, Minnesota, United States
Recruiting
Premier Imaging
Kansas City, Missouri, United States
Recruiting
St. Joseph Medical Center
Kansas City, Missouri, United States
Recruiting
MidAmerica Cancer Care - American Oncology Partners
Kansas City, Missouri, United States
Recruiting
Nebraska Medicine
Omaha, Nebraska, United States
Recruiting
Nebraska Medicine - Village Pointe
Omaha, Nebraska, United States
Recruiting
University of Nebraska Medical Center
Omaha, Nebraska, United States
Recruiting
Renown Health Medical Oncology
Reno, Nevada, United States
Recruiting
Renown Office of Clinical Research
Reno, Nevada, United States
Recruiting
Renown Regional Medical Center
Reno, Nevada, United States
Recruiting
Atlantic Health System / Morristown Medical Center
Morristown, New Jersey, United States
Recruiting
Showing 60 of 223 sites — filter to narrow it down. 212 of the 223 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT06989437. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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