This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.
A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF MEVROMETOSTAT (PF-06821497) WITH ENZALUTAMIDE IN METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER (MEVPRO-3)
- Metastatic Castration Sensitive Prostate Cancer (mCSPC)
- Hormone Sensitive Prostate Cancer
- Prostate Cancer
- Cancer of the Prostate
At a glance
- Phase
- Phase 3
- Study type
- Interventional
- Sponsor
- Pfizer
- Enrolment target
- 1,000
- Started
- 28 September 2025
- Main results due
- 12 September 2028
- Study sites
- 307
- Registry updated
- 24 September 2026
Can you take part?
- Aged 18 years and over.
- Men only.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria * Male participants aged ≥18 years (or the minimum age of consent in accordance with local regulations) at screening. * Histologically or cytologically confirmed adenocarcinoma of the prostate without small cell features. * Metastatic prostate cancer documented by positive bone scan (for bone disease) or metastatic lesion(s) on CT or MRI (for soft tissue/visceral disease). * Resolution of acute effects of any prior therapy to either baseline severity or CTCAE Grade ≤1 (except for AEs which do not constitute a safety risk in the investigator's judgement). * Participants must have ECOG PS 0 or 1. Exclusion Criteria * Any medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or, in the investigator's judgment, make the participant inappropriate for the study. * Clinically significant cardiovascular disease. * Known or suspected brain metastasis or active leptomeningeal disease. * Participants must be treatment naïve at the mCSPC stage, eg, participants cannot have received any cytotoxic chemotherapy with the following exceptions: Treatment with first-generation antiandrogen (ADT) agents is allowed for mCSPC. * Previous administration with an investigational product (drug or vaccine) within 30 days. * Use of 5-alpha reductase inhibitors is prohibited within 28 days of randomization. * Prior surgery from which the participant has not fully recovered at least 28 days prior to randomization * Current use or anticipated need for drugs that are known strong CYP3A4/5 inhibitors and inducers (with exception of enzalutamide as part of this study). * Inadequate organ function. * Known allergic or hypersensitivity reactions to mevrometostat or its excipients or to enzalutamide or its excipients.
What this study is about
In the sponsor’s own words, from the registry.
This study will explore whether a combination of the investigational drug mevrometostat (PF-06821497) and enzalutamide will work better than taking enzalutamide alone in participants with mCSPC who are ARPI naïve and have not yet received chemotherapy in the mCSPC setting.
Study sites(307)
Clearview Cancer Institute (Crestwood)
Huntsville, Alabama, United States
Recruiting
Clearview Cancer Institute
Huntsville, Alabama, United States
Recruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Chandler, Arizona, United States
Recruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Gilbert, Arizona, United States
Recruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Glendale, Arizona, United States
Recruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Goodyear, Arizona, United States
Recruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Mesa, Arizona, United States
Recruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Mesa, Arizona, United States
Recruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Phoenix, Arizona, United States
Recruiting
Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers
Scottsdale, Arizona, United States
Recruiting
Highlands Oncology Group, PA
Fayetteville, Arkansas, United States
Recruiting
Highlands Oncology Group, PA
Rogers, Arkansas, United States
Recruiting
Highlands Oncology Group, PA
Springdale, Arkansas, United States
Recruiting
UCLA Hematology/Oncology - Alhambra
Alhambra, California, United States
Recruiting
UCLA Hematology/Oncology - Atascadero
Atascadero, California, United States
Recruiting
Cedars-Sinai Cancer Beverly Hills (drug treatment and dispensing location)
Beverly Hills, California, United States
Recruiting
Cedars-Sinai Cancer Beverly Hills
Beverly Hills, California, United States
Recruiting
UCLA Hematology/Oncology - Beverly Hills
Beverly Hills, California, United States
Recruiting
UCLA Hematology/Oncology - Burbank
Burbank, California, United States
Recruiting
UCLA Hematology/Oncology - Encino
Encino, California, United States
Recruiting
UCLA Hematology/Oncology - Irvine
Irvine, California, United States
Recruiting
UCLA Hematology/Oncology - Laguna Hills
Laguna Hills, California, United States
Recruiting
Cedars-Sinai Cancer at Cedars-Sinai Medical Center
Los Angeles, California, United States
Recruiting
Ronald Reagan UCLA Medical Center - Drug Information Center
Los Angeles, California, United States
Recruiting
UCLA Department of Medicine - Hematology/Oncology
Los Angeles, California, United States
Recruiting
UCLA Hematology/Oncology
Los Angeles, California, United States
Recruiting
UCLA Hematology/Oncology - Marina del Rey
Marina del Rey, California, United States
Recruiting
UCLA Hematology/Oncology - Pasadena
Pasadena, California, United States
Recruiting
UCLA Hematology/Oncology - Porter Ranch
Porter Ranch, California, United States
Recruiting
UCLA Hematology/Oncology - San Luis Obispo
San Luis Obispo, California, United States
Recruiting
UCLA Hematology/Oncology - Santa Barbara
Santa Barbara, California, United States
Recruiting
UCLA Hematology/Oncology- Santa Monica
Santa Monica, California, United States
Recruiting
UCLA Hematology/Oncology - Torrance
Torrance, California, United States
Recruiting
UCLA Hematology/Oncology - Santa Clarita
Valencia, California, United States
Recruiting
UCLA Hematology/Oncology - Ventura
Ventura, California, United States
Recruiting
UCLA Hematology/Oncology - Westlake
Westlake Village, California, United States
Recruiting
AdventHealth Medical Group Urology of Denver
Denver, Colorado, United States
Recruiting
Advanced Urology Institute, LLC
Largo, Florida, United States
Recruiting
Tennessee Oncology, PLLC - Dalton
Dalton, Georgia, United States
Recruiting
Tennessee Oncology, PLLC - Ringgold
Ringgold, Georgia, United States
Recruiting
Associated Urological Specialists - Chicago Ridge
Chicago Ridge, Illinois, United States
Recruiting
Cancer Care Specialists of Illinois
Decatur, Illinois, United States
Recruiting
Cancer Care Specialists of Illinois
O'Fallon, Illinois, United States
Recruiting
Michigan Institute of Urology, PC
Troy, Michigan, United States
Recruiting
MSK Basking Ridge
Basking Ridge, New Jersey, United States
Recruiting
MSK Monmouth
Middletown, New Jersey, United States
Recruiting
MSK Bergen
Montvale, New Jersey, United States
Recruiting
MSK Commack
Commack, New York, United States
Recruiting
MSKCC-Westchester (500 Westchester Ave.)
Harrison, New York, United States
Recruiting
Integrated Medical Professionals
Lake Success, New York, United States
Recruiting
Memorial Sloan Kettering Cancer Center (IDS Pharmacy)
Long Island City, New York, United States
Recruiting
Evelyn H. Lauder Breast and Imaging Center (BAIC).
New York, New York, United States
Recruiting
Memorial Sloan Kettering Cancer Center - Main Campus
New York, New York, United States
Recruiting
Sidney Kimmel Center for Prostate and Urological Cancers - Memorial Sloan Kettering Cancer Center
New York, New York, United States
Recruiting
University of Rochester Medical Center
Rochester, New York, United States
Recruiting
University of Rochester, Cancer Center Pharmacy (Investigational Product)
Rochester, New York, United States
Recruiting
Integrated Medical Professionals
Seaford, New York, United States
Recruiting
Montefiore Einstein Comprehensive Cancer Center
The Bronx, New York, United States
Recruiting
Montefiore Medical Center- Montefiore Medical Park
The Bronx, New York, United States
Recruiting
MSK Nassau.
Uniondale, New York, United States
Recruiting
Showing 60 of 307 sites — filter to narrow it down. 140 of the 307 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07028853. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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