Comparison of Adenoma Detection Rate in 3D vs. 2D Surveillance Colonoscopy
Comparison of the Performance Between Conventional Colonoscopy and 3D Colonoscopy in Surveillance Colonoscopy: A Multi-center, Randomized Controlled Trial
- Colonoscopy
- Adenoma Detection Rate
- Three Dimensional
- Colon Polyps and Adenomas
At a glance
- Phase
- Phase not stated
- Study type
- Interventional
- Sponsor
- National Taiwan University Hospital
- Enrolment target
- 660
- Started
- 1 January 2024
- Main results due
- 31 December 2026
- Study sites
- 3
- Registry updated
- 29 September 2026
Can you take part?
- Aged 40 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Subjects who are 40 years of older * Subjects who receive colonoscopy and polypectomy more the 1 year * Subjects who need surveillance colonoscopy Exclusion Criteria: * Contraindication for colonoscopy * Subjects with familiar or hereditary polyposis * Subjects with history of colectomy * Inadequate bowel cleansing level * Subjects with inflammatory bowel disease
What this study is about
In the sponsor’s own words, from the registry.
There is substantial evidence confirming that identifying and removing colorectal adenomas during colonoscopy helps prevent the development of colorectal cancer. Among the quality indicators for colonoscopy, adenoma detection rate (ADR) is the most important, as it is closely related to the patient's future risk of colorectal cancer. Recent studies have further demonstrated that improving ADR can reduce future mortality from colorectal cancer. Notably, non-polypoid lesions (such as flat or depressed lesions) are more likely to be missed during traditional colonoscopy, making these lesions a leading cause of post-colonoscopy interval colorectal cancer.
In a prospective trial conducted by our team comparing the ADR of 3D colonoscopy with standard 2D colonoscopy, we found that 3D colonoscopy significantly improved overall ADR and the detection rate of non-polypoid adenomas.
According to current international guidelines, after an index colonoscopy, patients are recommended to undergo surveillance colonoscopy 1 to 10 years later, depending on their findings at index colonoscopy. Since these patients represent the majority in clinical practice, increasing the ADR during surveillance colonoscopy not only allows for more precise recommendations for the timing of the next colonoscopy but also effectively reduces the risk of post-colonoscopy colorectal cancer (PCCRC).
Therefore, this multicenter, prospective, randomized trial aims to compare the clinical performance of 3D colonoscopy and standard 2D colonoscopy in the context of surveillance colonoscopy.
Study sites(3)
National Taiwan University Hospital, Hsinchu Branch
Hsinchu, Taiwan
Recruiting
National Taiwan University Cancer Center
Taipei, Taiwan
Recruiting
National Taiwan University Hospital
Taipei, Taiwan
Recruiting
Showing 3 of 3 sites. 3 of the 3 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07076966. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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