A Study to Assess the Efficacy and Safety of Empasiprubart in Adults With CIDP
A Phase 3, Randomized, Double-Blinded, Placebo-Controlled Study Evaluating the Efficacy and Safety of Empasiprubart IV in Adults With Chronic Inflammatory Demyelinating Polyneuropathy
- Chronic Inflammatory Demyelinating Polyneuropathy
- CIDP
- Chronic Inflammatory Demyelinating Polyradiculoneuropathy
At a glance
- Phase
- Phase 3
- Study type
- Interventional
- Sponsor
- argenx
- Enrolment target
- 160
- Started
- 16 September 2025
- Main results due
- 7 October 2027
- Study sites
- 85
- Registry updated
- 24 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Meets criteria for CIDP based on EAN/PNS Task Force CIDP guidelines, second revision (2021) * Has either typical CIDP or 1 of the following CIDP variants: motor CIDP (including motor-predominant CIDP), multifocal CIDP (also known as Lewis-Sumner syndrome), focal CIDP, or distal CIDP * Has residual disability and active disease * Has not received previous treatment for CIDP; or has stopped receiving CIDP treatment; or is receiving CIDP treatment (pulsed or oral corticosteroids, immunoglobulins, PLEX, or FcRn inhibitors) * Participants already receiving CIDP treatment will have to discontinue their CIDP treatment before first IMP administration and must be willing to switch to the study IMP Exclusion Criteria: * Meets the criteria for possible CIDP based on EAN/PNS Task Force CIDP guidelines, second revision (2021) * Sensory CIDP (including sensory-predominant CIDP) * Polyneuropathy of other causes * Clinical diagnosis of systemic lupus erythematosus (SLE) * Use of other long-acting immunomodulatory treatment or prior treatment (at any time) with total lymphoid irradiation or bone marrow transplantation
What this study is about
In the sponsor’s own words, from the registry.
The main purpose of this study is to demonstrate the efficacy and safety of empasiprubart in adults with CIDP. The study consists of a part A where participants will either receive empasiprubart or placebo for 24 weeks (6 months). Following part A, participants will enter part B in which all participants will receive empasiprubart for 96 weeks (24 months).
More information can be found here: https://clinicaltrials.argenx.com/emnergize
Study sites(85)
University of Alabama at Birmingham - 1720 University Blvd
Birmingham, Alabama, United States
Recruiting
Samir Macwan, M.D., Inc. (S corporation)
Rancho Mirage, California, United States
Recruiting
Colorado Springs Neurological Associates
Colorado Springs, Colorado, United States
Recruiting
Medstar Health Research Institute
Washington D.C., District of Columbia, United States
Recruiting
Gables Neurology
Miami, Florida, United States
Recruiting
Aqualane Clinical Research
Naples, Florida, United States
Recruiting
Paradigm Health System
Slidell, Louisiana, United States
Recruiting
Penn Medicine University City
Philadelphia, Pennsylvania, United States
Recruiting
Jefferson Health Honickman Center
Philadelphia, Pennsylvania, United States
Recruiting
University Neurology
Knoxville, Tennessee, United States
Recruiting
National Neuromuscular Research Institute
Austin, Texas, United States
Recruiting
NeuroCarePlus
Houston, Texas, United States
Recruiting
Instituto Privado Kremer
Córdoba, Argentina
Recruiting
Instituto Médico de la Fundación Estudios Clínicos
Rosario, Argentina
Recruiting
INECO Neurociencias Oroño
Rosario, Argentina
Recruiting
Kepler Universitätsklinikum Linz - Med Campus III
Linz, Upper Austria, Austria
Recruiting
Universitätsklinikum AKH Wien
Vienna, Austria
Recruiting
Unidade de Pesquisa Clinica e Inovacao da Estacio
Rio de Janeiro, Rio de Janeiro, Brazil
Recruiting
Hospital de Clinicas de Porto Alegre (HCPA) - PPDS
Pôrto Alegre, Rio Grande do Sul, Brazil
Recruiting
Hospital Das Clinicas da Faculdade de Medicina de Ribeirao Preto - UPS - PPDS
Ribeirão Preto, São Paulo, Brazil
Recruiting
L2 Ip - Instituto de Pesquisas Clinicas Ltda - ME
Brasília, Brazil
Recruiting
Hospital Moinhos de Vento
Porto Alegre, Brazil
Recruiting
PSEG Centro de Pesquisa Clinica
São Paulo, Brazil
Recruiting
Multiprofile Hospital for Active Treatment of Neurology and Psychiatry Sv. Naum EAD
Sofia, Sofia, Bulgaria
Recruiting
University Multiprofile Hospital for Active Treatment
Pleven, Bulgaria
Recruiting
Medical Center Medika 2005 - Branch Sofia
Sofia, Bulgaria
Recruiting
University Multiprofile Hospital for Active Treatment Aleksandrovska EAD
Sofia, Bulgaria
Recruiting
University Multiprofile Hospital for Active Treatment and Emergency Medicine N. I. Pirogov EAD
Sofia, Bulgaria
Recruiting
Fujian Medical University Union Hospital - Yushan Campus
Fuzhou, Fujian, China
Recruiting
The People's Hospital of Baiyun District Guangzhou
Guangzhou, Guangdong, China
Recruiting
Peking University First Hospital - Changqiao Campus
Beijing, China
Recruiting
Guangdong Provincial Hospital of Chinese Medicine
Guangzhou, China
Recruiting
Nanfang Hospital Southern Medical University
Guangzhou, China
Recruiting
Xi'an Gaoxin Hospital
Xi'an, China
Recruiting
Fakultni nemocnice Brno
Brno, Czechia
Recruiting
Rigshospitalet
Copenhagen, Denmark
Recruiting
Astra Kliinik
Tallinn, Estonia
Recruiting
CHU de Lille - Hôpital Roger Salengro
Lille, Nord, France
Recruiting
AP-HP - Hôpital de la Pitié Salpétrière
Paris, Paris, France
Recruiting
AP-HP - Hôpital Henri Mondor
Créteil, Val-de-Marne, France
Recruiting
CHU de Bordeaux - Hôpital
Bourdeaux, France
Recruiting
CHU de Nice-Hôpital Pasteur
Nice, France
Recruiting
High Technology Hospital MedCenter Ltd
Batumi, Georgia
Recruiting
First Medical Clinic LLC
Batumi, Georgia
Recruiting
Petre Sarajishvili Institute of Neurology
Tbilisi, Georgia
Recruiting
Aleksandre Aladashvili Clinic
Tbilisi, Georgia
Recruiting
Curatio JSC
Tbilisi, Georgia
Recruiting
LTD New Hospitals
Tbilisi, Georgia
Recruiting
Geo Hospitals
Tbilisi, Georgia
Recruiting
Jo Ann Medical Center
Tbilisi, Georgia
Recruiting
University General Hospital of Alexandroupolis
Alexandroupoli, Evros, Greece
Recruiting
Eginitio Hospital
Athens, Greece
Recruiting
Semmelweis Egyetem Genomikai Medicina és Ritka Betegségek Intézete
Budapest, Hungary
Recruiting
Hillel Yaffe Medical Center
Hadera, Israel
Recruiting
The Chaim Sheba Medical Center - PPDS
Ramat Gan, Israel
Recruiting
Fondazione Serena Onlus - Centro Clinico NeMO Brescia
Gussago, Brescia, Italy
Recruiting
Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI) - Ospedale di Cattinara
Trieste, Friuli-VeneziaGiulia, Italy
Recruiting
IRCCS Istituto delle Scienze Neurologiche di Bologna
Bologna, Italy
Recruiting
IRCCS Azienda Ospedaliera Metropolitana - Ospedale Policlinico San Martino
Genova, Italy
Recruiting
Ospedale San Raffaele S.r.l.
Milan, Italy
Recruiting
Showing 60 of 85 sites — filter to narrow it down. 85 of the 85 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07091630. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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