NCT07157774From ClinicalTrials.govRecruiting

Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Effect of Muvalaplin on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) Who Have Had a Prior Atherosclerotic Cardiovascular Event or Are at Risk for a First Atherosclerotic Cardiovascular Event

Elevated Lp(a)
Atherosclerotic Cardiovascular Disease (ASCVD)

At a glance

Phase: Phase 3
Study type: Interventional
Sponsor: Eli Lilly and Company
Enrolment target: 10,450
Started: 2 September 2025
Main results due: March 2031
Study sites: 804
Registry updated: 24 September 2026

Can you take part?

Aged 18 years and over.
Open to any sex.
You need the condition being studied — healthy volunteers are not accepted.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria

Inclusion Criteria:

* Have Lp(a) ≥175 nanomoles per liter (nmol/L)
* Meet one of the following criteria:

  * Have had a prior atherosclerotic cardiovascular disease (ASCVD) event (such as heart attack, stroke, or procedure to restore blood flow to the heart or other parts of the body) within 10 years prior to screening
  * Are at risk for a first ASCVD event, defined as one or more of the following:

    * Documented coronary artery disease (CAD), carotid stenosis, or peripheral artery disease (PAD) without a history of ASCVD event
    * A high coronary artery calcium (CAC) score
    * Reduced kidney function with diabetes
    * Combination(s) of high risk factors

Exclusion Criteria:

* Have experienced a major cardiovascular event or surgery, such as heart attack, stroke, or procedure to restore blood flow to the heart or other parts of the body, within 90 days prior to screening or occurring between screening and randomization
* Are planning or expected to undergo a procedure to restore blood flow in the arteries or a major heart surgery during the study
* Have uncontrolled high blood pressure
* Have New York Heart Association (NYHA) class III or IV heart failure
* Have undergone a procedure to remove cholesterol from the blood within 90 days of screening, or have a planned procedure during the study
* Have severe kidney impairment
* Have had cancer within 5 years prior to screening

What this study is about

In the sponsor’s own words, from the registry.

The purpose of this study is to evaluate the efficacy of muvalaplin in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke.

Study sites(804)

Birmingham Clinical Research
Birmingham, Alabama, United States
Not yet recruiting
Smiths Medical Center
Apache Junction, Arizona, United States
Not yet recruiting
Phoenix Medical Trials
Gilbert, Arizona, United States
Not yet recruiting
Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC
Gilbert, Arizona, United States
Recruiting
Onyx Clinical Research
Phoenix, Arizona, United States
Recruiting
Clinical Research Institute of Arizona (CRI) - Sun City West
Sun City West, Arizona, United States
Recruiting
Southwest Kidney Institute - Surprise
Surprise, Arizona, United States
Recruiting
Pima Heart
Tucson, Arizona, United States
Recruiting
Eclipse Clinical Research
Tucson, Arizona, United States
Recruiting
National Heart Institute
Beverly Hills, California, United States
Recruiting
John Muir Medical Center - Concord Campus
Concord, California, United States
Recruiting
Neighborhood Healthcare Institute of Health
Escondido, California, United States
Recruiting
Ark Clinical Research - Fountain Valley
Fountain Valley, California, United States
Recruiting
Thrive Clinical Research Group
Glendora, California, United States
Not yet recruiting
Care Access - Huntington Beach
Huntington Beach, California, United States
Recruiting
310 Clinical Research
Inglewood, California, United States
Not yet recruiting
Scripps Whittier Diabetes Institute
La Jolla, California, United States
Not yet recruiting
The Cardiovascular Center
Redding, California, United States
Recruiting
FOMAT Medical Research - Santa Maria
Santa Maria, California, United States
Not yet recruiting
Integrated Clinical Research
Sherman Oaks, California, United States
Not yet recruiting
UCLA South Bay Endocrinology
Torrance, California, United States
Recruiting
Lynn Institute of Denver
Aurora, Colorado, United States
Not yet recruiting
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States
Recruiting
Legacy Clinical Trials
Colorado Springs, Colorado, United States
Recruiting
OptumCare Clinical Trials, LLC
Golden, Colorado, United States
Completed
Cardiology Associates of Fairfield County, P.C.
Stamford, Connecticut, United States
Recruiting
Chase Medical Research, LLC
Waterbury, Connecticut, United States
Recruiting
Excel Medical Clinical Trials
Boca Raton, Florida, United States
Recruiting
FWD Clinical Research
Boca Raton, Florida, United States
Completed
American Research Institute
Cutler Bay, Florida, United States
Recruiting
K2 Medical Research - Daytona Beach
Daytona Beach, Florida, United States
Recruiting
Arrow Clinical Trials
Daytona Beach, Florida, United States
Recruiting
Soffer Health Institute
Hollywood, Florida, United States
Recruiting
Jacksonville Center for Clinical Research
Jacksonville, Florida, United States
Recruiting
K2 MEDICAL Research THE VILLAGES
Lady Lake, Florida, United States
Recruiting
Clinical Research of Central Florida
Lakeland, Florida, United States
Not yet recruiting
K2 Medical Research - Maitland
Maitland, Florida, United States
Recruiting
K2 Medical Research ORLANDO
Maitland, Florida, United States
Recruiting
Dade Florida Clinical Research Center
Miami, Florida, United States
Recruiting
Onhealth Research Center
Miami, Florida, United States
Recruiting
Floridian Clinical Research, LLC
Miami Lakes, Florida, United States
Not yet recruiting
Advanced Research for Health Improvement, LLC
Naples, Florida, United States
Recruiting
Renstar Medical Research
Ocala, Florida, United States
Recruiting
Florida Institute For Clinical Research, LLC
Orlando, Florida, United States
Not yet recruiting
Precision Clinical Research
Sunrise, Florida, United States
Not yet recruiting
Care Access - Tamarac
Tamarac, Florida, United States
Recruiting
Care Access - Tampa
Tampa, Florida, United States
Recruiting
Southeastern Clinical Research Institute
Augusta, Georgia, United States
Recruiting
Masters of Clinical Research
Augusta, Georgia, United States
Recruiting
Center for Advanced Research & Education
Gainesville, Georgia, United States
Recruiting
NSC Research
Johns Creek, Georgia, United States
Not yet recruiting
North Georgia Clinical Research
Woodstock, Georgia, United States
Recruiting
Elite Clinical Trials
Blackfoot, Idaho, United States
Recruiting
High Desert Heart & Vascular
Meridian, Idaho, United States
Recruiting
Elite Clinical Trials
Rexburg, Idaho, United States
Recruiting
Great Lakes Clinical Trials - Ravenswood
Chicago, Illinois, United States
Recruiting
Clinical Investigation Specialists
Gurnee, Illinois, United States
Recruiting
Accellacare - DuPage
Lombard, Illinois, United States
Not yet recruiting
AMR Clinical
Niles, Illinois, United States
Recruiting
Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative
Springfield, Illinois, United States
Not yet recruiting

Showing 60 of 804 sites — filter to narrow it down. 716 of the 804 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT07157774. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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