Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lactams
- Community-acquired Pneumonia
At a glance
- Phase
- Phase 4
- Study type
- Interventional
- Sponsor
- Mayo Clinic
- Enrolment target
- 1,120
- Started
- 15 September 2025
- Main results due
- 1 September 2030
- Study sites
- 5
- Registry updated
- 24 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: • All adult patients (\>18 years old) admitted with CAP and receiving a beta-lactam antibiotic plus a form of atypical coverage (azithromycin or doxycycline) in the ED within 12 hours of admission. Exclusion Criteria: * High clinical suspicion for Legionella pneumonia * Allergy or contraindication to the use of either azithromycin or doxycycline (usual clinical practice) * Antibiotics not for CAP * Pregnant women (based on clinical assessment as part of standard of care) * Severe CAP as defined by the ATS/IDSA criteria * Corrected QT prolongation (\> 450 ms in men and \> 460 ms in women) * Incarcerated individuals (prisoner)
What this study is about
In the sponsor’s own words, from the registry.
The purpose of this study is to compare effectiveness and safety of Azithromycin versus Doxycycline in adult patients hospitalized with community acquired pneumonia (CAP) treated with Beta-lactams.
Study sites(5)
Mayo Clinic in Arizona
Scottsdale, Arizona, United States
Not yet recruiting
Mayo Clinic in Florida
Jacksonville, Florida, United States
Not yet recruiting
Mayo Clinic Health System-Mankato
Mankato, Minnesota, United States
Not yet recruiting
Mayo Clinic in Rochester
Rochester, Minnesota, United States
Recruiting
Mayo Clinic Health System-La Crosse
La Crosse, Wisconsin, United States
Not yet recruiting
Showing 5 of 5 sites. 1 of the 5 sites on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07164131. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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