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NCT07171281From ClinicalTrials.govRecruiting

Precise Eating Time to Improve Glycemic Control and Cardiometabolic Health in Prediabetes and Diabetes

Precise Eating Time to Improve Glycemic Control and Cardiometabolic Health in Prediabetes and Diabetes: the GLYCOTIME Trial

  • Prediabetes
  • Type 2 Diabetes
  • Obesity &Amp; Overweight

At a glance

Phase
Phase not stated
Study type
Interventional
Sponsor
German Institute of Human Nutrition
Enrolment target
30
Started
1 October 2025
Main results due
31 December 2027
Study sites
1
Registry updated
29 September 2026

Can you take part?

  • Ages 18 years to 75 years.
  • Open to any sex.
  • Healthy volunteers can take part.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria
Inclusion Criteria:

* Overweight or obesity (BMI 25-40 kg/m²)
* Healthy glucose metabolism (fasting glucose \<100 mg/dl and glucose after 2 hours OGTT \<140 mg/dl)
* OR impaired glucose metabolism (fasting glucose 100-125 mg/dl and/or glucose after 2 hours OGTT 140-199 mg/dl and/or HbA1c 5.7-6.4%)
* OR type 2 diabetes (according to existing medical diagnosis or fasting glucose \>126 mg/dl and/or glucose after 2 hours OGTT \>200 mg/dl and/or HbA1c ≥6.5%)
* Daily eating window ≥12 hours

Exclusion Criteria:

* Weight changes \> 5% within past 3 months
* Shift work
* Traveling across more than one time zone within one month prior to the study
* Pregnancy and breastfeeding
* Eating disorders, food intolerance/allergy to ingredients in the diet product, vegan diet, practicing time-restricted eating
* Severe chronic illnesses or other conditions that are incompatible with the planned intervention and examination program (e.g. type 1 diabetes, recent cardiovascular event, malabsorption, cancer in the last two years, etc.)
* Treatment with insulin, sulfonylureas, and GLP-1 receptor agonists, steroid use (oral, cutaneous, or parenteral), regular intake of melatonin, anticoagulation treatment that cannot be paused
* Extreme early and extreme late chronotypes

What this study is about

In the sponsor’s own words, from the registry.

The objective of this study is to investigate the impact of hypocaloric time-restricted eating (TRE) at different day times (early versus late TRE) on glucose metabolism and other cardiometabolic parameters in individuals with overweight and with normal, or impaired glucose metabolism (prediabetes and type 2 diabetes). In addition, the study aims to elucidate the molecular mechanisms underlying these effects.

Study sites(1)

  • German Institute of Human Nutrition Potsdam-Rehbruecke

    Nuthetal, Germany

    Recruiting

Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT07171281. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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Precise Eating Time to Improve Glycemic Control and Cardiometabolic Health in Prediabetes and Diabetes | Trialion