Effect of Protocolized Magnesium Replacement on Mortality and Atrial Fibrillation in Critically Ill Patients
Effect of Protocolized Magnesium Replacement in Critically Ill Patients on Mortality and Atrial Fibrillation: the MAGNOLIA Randomized Controlled Trial
- Critical Illness
At a glance
- Phase
- Phase 4
- Study type
- Interventional
- Sponsor
- Scarborough General Hospital
- Enrolment target
- 3,853
- Started
- 25 November 2025
- Main results due
- 1 March 2027
- Study sites
- 6
- Registry updated
- 24 September 2026
Can you take part?
- Aged 16 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Age 16 years or older * Admission orders written to a medical-surgical intensive care unit at a participating site * Magnesium replacement protocol ordered Exclusion Criteria: * Prior enrollment in or withdrawal from MAGNOLIA trial * Sustained ventricular tachycardia * Pre-eclampsia * Myasthenia gravis
What this study is about
In the sponsor’s own words, from the registry.
In patients with critical illness, such as severe infections, heart attacks, or respiratory failure, most intensive care units (ICUs) measure magnesium levels and give supplemental doses of magnesium when levels are below certain targets. However, the best targets are unknown. The goal of this clinical trial is to study protocols for magnesium supplementation in people with critical illness, comparing a protocol with higher target level to a protocol with a lower target level.
The main question this study aims to answer is whether magnesium supplementation protocols targeting a higher or lower level lead to better 30-day survival and less atrial fibrillation.
Participants will not have to do any specific tasks, undergo any additional tests, or complete any surveys.
Study sites(6)
Lakeridge Health Ajax-Pickering
Ajax, Ontario, Canada
Recruiting
Lakeridge Health Bowmanville
Bowmanville, Ontario, Canada
Recruiting
Lakeridge Health Oshawa
Oshawa, Ontario, Canada
Recruiting
Scarborough Centenary Hospital
Toronto, Ontario, Canada
Recruiting
Scarborough General Hospital
Toronto, Ontario, Canada
Recruiting
Scarborough Birchmount Hospital
Toronto, Ontario, Canada
Recruiting
Showing 6 of 6 sites. 6 of the 6 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07173855. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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