Scrambler Therapy in Chronic Pancreatitis
A Pilot Study of Scrambler Therapy for Painful Chronic Pancreatitis
- Chronic Pain
- Pancreatitis
- Chronic Pancreatitis
At a glance
- Phase
- Phase not stated
- Study type
- Interventional
- Sponsor
- Johns Hopkins University
- Enrolment target
- 40
- Started
- 1 November 2024
- Main results due
- 1 December 2026
- Study sites
- 1
- Registry updated
- 29 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Adults aged 18 years and older * Diagnosis of chronic pancreatitis with refractory abdominal pain * Able to provide written informed consent in English * Sufficient English language ability to complete study questionnaires * Reliable and regular access to a phone for follow-up Exclusion Criteria: * Unable or unwilling to provide written consent * History or presence of a significant medical or psychiatric condition that would interfere with study participation * Pregnant or lactating women * Coronary stents or implanted metallic/electrical devices (pacemaker, defibrillator, aneurysm clips) * History of epilepsy, traumatic brain injury, or myocardial infarction within the past 6 months * Skin conditions preventing electrode placement (e.g., open wounds) * Any condition that, in the investigator's opinion, places the participant at increased risk or prevents full compliance with study procedures
What this study is about
In the sponsor’s own words, from the registry.
The investigators will enroll adults with chronic pancreatitis who have persistent abdominal pain not relieved by standard treatments. This study will test the feasibility and effectiveness of Scrambler Therapy, a non-invasive FDA-cleared device that delivers "non-pain" electrical signals through the skin to retrain the brain's pain perception. Participants will undergo 5-10 treatment sessions and be followed for 3 months with standardized pain scores and quality-of-life assessments. The goal is to generate pilot data to support larger studies of Scrambler Therapy as a novel option for pancreatic pain.
Study sites(1)
Johns Hopkins Green Spring Station
Baltimore, Maryland, United States
Recruiting
Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07174609. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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