Symbiotic-Lung-04: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Extensive-Stage Small Cell Lung Cancer
A GLOBAL PHASE 2/3 INTERVENTIONAL STUDY OF PF-08634404 IN COMBINATION WITH CHEMOTHERAPY IN PARTICIPANTS WITH EXTENSIVE STAGE SMALL CELL LUNG CANCER
- Small Cell Lung Cancer (SCLC)
At a glance
- Phase
- Phase 2
- Study type
- Interventional
- Sponsor
- Pfizer
- Enrolment target
- 550
- Started
- 9 December 2025
- Main results due
- 14 June 2030
- Study sites
- 82
- Registry updated
- 28 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Histologically or cytologically confirmed extensive-stage small cell lung cancer (ES-SCLC). * Participants have not received systemic therapy (chemotherapy, radiotherapy, chemoradiation) for ES-SCLC. * Treatment-free for at least 6 months since last chemo/radiotherapy, among those treated (with curative intent) with prior chemo/radiotherapy for limited-stage SCLC * Have at least one measurable lesion as the targeted lesion based on RECIST V1.1. * Eastern Cooperative Oncology Group performance status of 0 or 1. * Adequate organ function Exclusion Criteria: * known active CNS lesions, including brainstem, meningeal, or spinal cord metastases or compression * Leptomeningeal disease * Clinically significant risk of hemorrhage or fistula * history of another malignancy within 3 years * active autoimmune diseases requiring systemic treatment within the past 2 years
What this study is about
In the sponsor’s own words, from the registry.
This study is being done to learn more about a new medicine called PF-08634404 and how well it works when given with chemotherapy to adults with extensive-stage small cell lung cancer (ES-SCLC), a fast-growing type of lung cancer that has spread widely in the body.
To join the study, participants must meet the following conditions:
* Be 18 years or older. * Have extensive-stage small cell lung cancer confirmed by lab tests. * Have not received chemotherapy or radiation for this type of lung cancer. * Be in good physical condition and have healthy organs based on medical tests.
The study has two parts:
* In the first part, researchers will check how safe the study medicine is and how well people tolerate it when given with chemotherapy. * In the second part, they will compare study medicine plus chemotherapy to another approved treatment (atezolizumab plus chemotherapy) to see which works better.
Participants will receive the treatment through IV infusions (medicine given directly into a vein). The treatment will be given in repeated time periods called cycles. Some participants will continue receiving the study medicine alone after the initial treatment.
Study sites(82)
Highlands Oncology Group
Fayetteville, Arkansas, United States
Recruiting
Highlands Oncology Group
Rogers, Arkansas, United States
Recruiting
Highlands Oncology Group
Springdale, Arkansas, United States
Recruiting
BRCR Coral Springs
Coral Springs, Florida, United States
Recruiting
Mid Florida Hematology and Oncology Center
Orange City, Florida, United States
Recruiting
BRCR Global - Tamarac
Tamarac, Florida, United States
Recruiting
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States
Recruiting
Texas Oncology - Northeast Texas
Allen, Texas, United States
Recruiting
Texas Oncology - DFW
Arlington, Texas, United States
Recruiting
Texas Oncology - DFW
Arlington, Texas, United States
Recruiting
Texas Oncology - Gulf Coast
Beaumont, Texas, United States
Recruiting
Texas Oncology - DFW
Bedford, Texas, United States
Recruiting
Texas Oncology - DFW
Dallas, Texas, United States
Recruiting
Texas Oncology - DFW
Dallas, Texas, United States
Recruiting
Texas Oncology - DFW
Dallas, Texas, United States
Recruiting
Texas Oncology - DFW
Dallas, Texas, United States
Recruiting
Texas Oncology - DFW
Dallas, Texas, United States
Recruiting
Texas Oncology - Northeast Texas
Denison, Texas, United States
Recruiting
Texas Oncology - Northeast Texas
Denton, Texas, United States
Recruiting
Texas Oncology - Northeast Texas
Flower Mound, Texas, United States
Recruiting
Texas Oncology - DFW
Fort Worth, Texas, United States
Recruiting
Texas Oncology - San Antonio
Fredericksburg, Texas, United States
Recruiting
Texas Oncology - DFW
Grapevine, Texas, United States
Recruiting
Texas Oncology - Gulf Coast
Houston, Texas, United States
Recruiting
Texas Oncology - Gulf Coast
Houston, Texas, United States
Recruiting
US Oncology Investigational Product Center (IPC)
Irving, Texas, United States
Recruiting
US Oncology Investigational Products Center (IPC)
Irving, Texas, United States
Recruiting
Texas Oncology - Northeast Texas
Lewisville, Texas, United States
Recruiting
Texas Oncology - Northeast Texas
Longview, Texas, United States
Recruiting
Texas Oncology - Northeast Texas
McKinney, Texas, United States
Recruiting
Texas Oncology - San Antonio
New Braunfels, Texas, United States
Recruiting
Texas Oncology - Northeast Texas
Palestine, Texas, United States
Recruiting
Texas Oncology - Northeast Texas
Paris, Texas, United States
Recruiting
Texas Oncology - Gulf Coast
Pearland, Texas, United States
Recruiting
Texas Oncology - DFW
Plano, Texas, United States
Recruiting
Texas Oncology - DFW
Plano, Texas, United States
Recruiting
Texas Oncology - San Antonio
San Antonio, Texas, United States
Recruiting
Texas Oncology - San Antonio
San Antonio, Texas, United States
Recruiting
Texas Oncology - San Antonio
San Antonio, Texas, United States
Recruiting
Texas Oncology - Gulf Coast
Sugar Land, Texas, United States
Recruiting
Texas Oncology - Gulf Coast
The Woodlands, Texas, United States
Recruiting
Texas Oncology - Northeast Texas
Tyler, Texas, United States
Recruiting
Texas Oncology - Gulf Coast
Webster, Texas, United States
Recruiting
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
Blacksburg, Virginia, United States
Recruiting
Virginia Oncology Associates
Chesapeake, Virginia, United States
Recruiting
Virginia Oncology Associates
Hampton, Virginia, United States
Recruiting
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
Low Moor, Virginia, United States
Recruiting
Virginia Oncology Associates
Newport News, Virginia, United States
Recruiting
Virginia Oncology Associates
Norfolk, Virginia, United States
Recruiting
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
Roanoke, Virginia, United States
Recruiting
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
Salem, Virginia, United States
Recruiting
Virginia Oncology Associates
Virginia Beach, Virginia, United States
Recruiting
Virginia Oncology Associates
Williamsburg, Virginia, United States
Recruiting
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
Wytheville, Virginia, United States
Recruiting
Westmead Hospital
Westmead, New South Wales, Australia
Recruiting
Sunshine Coast University Hospital
Birtinya, Queensland, Australia
Recruiting
Guangdong Provincial People's Hospital
Guangzhou, Guangdong, China
Recruiting
Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, China
Recruiting
Gustave Roussy
Villejuif, France
Recruiting
Hôpital Ambroise Paré
Boulogne-Billancourt, Île-de-France Region, France
Recruiting
Showing 60 of 82 sites — filter to narrow it down. 82 of the 82 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07226999. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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