NCT07227298From ClinicalTrials.govRecruiting

Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers

AN INTERVENTIONAL OPEN-LABEL PHASE 1B/2 STUDY TO EVALUATE THE SAFETY, PHARMACOKINETICS, AND PRELIMINARY EFFICACY OF PF-08634404 IN COMBINATION WITH DIFFERENT ANTICANCER AGENTS IN PARTICIPANTS WITH ADVANCED SOLID TUMORS

Advanced/Metastatic Non-Small Cell Lung Cancer
Carcinoma, Non-Small Cell Lung
Non-Small Cell Lung Cancer

At a glance

Phase: Phase 1
Study type: Interventional
Sponsor: Pfizer
Enrolment target: 162
Started: 30 January 2026
Main results due: 8 March 2029
Study sites: 90
Registry updated: 25 September 2026

Can you take part?

Aged 18 years and over.
Open to any sex.
You need the condition being studied — healthy volunteers are not accepted.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria

Inclusion Criteria:

* Pathologically confirmed locally advanced (Stage IIIB/IIIC) or metastatic (Stage IV) squamous or non-squamous NSCLC and are not a candidate for complete surgical resection and curative concurrent/sequential chemoradiotherapy
* PD-L1 status available
* Part B only: PD-L1 ≥ TPS 1%
* Measurable disease based on RECIST v1.1 per investigator.
* Eastern Cooperative Oncology Group performance status of 0 or 1.
* Adequate organ function

Exclusion Criteria:

* Participants with known AGAs including EGFR, ALK and ROS1, NTRK, BRAF, and MET for which there are available first-line therapies per local standard-of-care (SOC)
* History of another malignancy within 2 years before the first dose of study intervention, or any evidence of residual disease from a previously diagnosed malignancy
* Known active CNS lesions, including brainstem, meningeal, or spinal cord metastases or compression
* Leptomeningeal disease
* Active autoimmune diseases requiring systemic treatment within the past 2 years
* Previous systemic anti-tumor therapy for locally advanced or metastatic NSCLC
* Previous treatment with immunotherapy (exception is (neo)adjuvant or consolidation anti-PD-(L)1), ADCs containing MMAE payload, systemic anti-angiogenic therapy, or prior radiotherapy \>30 Gy to the lung within 6 months of first dose of study intervention

What this study is about

In the sponsor’s own words, from the registry.

This study is being done to learn more about a new medicine called PF-08634404 and how it works when used with other cancer medicines in people who have advanced solid tumors. An advanced solid tumor is a type of cancer that has spread beyond its original location and cannot be removed by surgery or cured with standard treatments.

To join in the study, participants must:

* Be 18 years or older * Participants with advanced non-small cell lung cancer (NSCLC), a type of lung cancer that has spread to other parts of the body

The study will look at:

* Whether PF-08634404 is safe to use with other cancer medicines. * What side effects may happen. A side effect is anything the medicine does to your body that is not part of treating your disease. * Whether the combination of PF-08634404 and other cancer medicines can help treat solid tumors.

The study has different parts, each testing PF-08634404 with a different cancer medicine:

* Part A will test PF-08634404 with a medicine called sigvotatug vedotin. * Part B will test PF-08634404 with a medicine called PF-08046054/SGN-PDL1V

Participants will receive the study medicines through an intravenous (IV) infusion (injected into the vein) at the study clinic. All treatments will take place at clinical trial sites, where trained medical staff will monitor participants during and after each visit.

Study sites(90)

Highlands Oncology Group, PA
Fayetteville, Arkansas, United States
Recruiting
Highlands Oncology Group, PA
Rogers, Arkansas, United States
Recruiting
Highlands Oncology Group, PA
Springdale, Arkansas, United States
Recruiting
Providence Medical Foundation
Fullerton, California, United States
Recruiting
Providence St. Jude Medical Center - Virginia K. Crosson Cancer Center and Infusion Center
Fullerton, California, United States
Recruiting
Providence St. Jude Medical Center
Fullerton, California, United States
Recruiting
Scripps Clinic Torrey Pines (Scripps Cancer Center)
La Jolla, California, United States
Recruiting
Scripps Green Hospital
La Jolla, California, United States
Recruiting
Scripps Shiley Pavilion
La Jolla, California, United States
Recruiting
START Los Angeles, LLC
Los Angeles, California, United States
Recruiting
LACN Century City
Los Angeles, California, United States
Recruiting
Valkyrie Clinical Trials (Additional Site Pharmacy Storage Suite)
Los Angeles, California, United States
Recruiting
Valkyrie Clinical Trials (Additional Site Suite)
Los Angeles, California, United States
Recruiting
Valkyrie Clinical Trials
Los Angeles, California, United States
Recruiting
Mission Community Hospital (Satellite Site)
Panorama City, California, United States
Recruiting
Rocky Mountain Cancer Centers,LLP
Aurora, Colorado, United States
Recruiting
Rocky Mountain Cancer Centers,LLP
Denver, Colorado, United States
Recruiting
Rocky Mountain Cancer Centers,LLP
Lone Tree, Colorado, United States
Recruiting
BRCR Medical Center Inc.
Coral Springs, Florida, United States
Recruiting
Mid Florida Hematology and Oncology Center
Orange City, Florida, United States
Recruiting
Orlando Health Ambulatory Care Center
Orlando, Florida, United States
Recruiting
Orlando Health Cancer Institute
Orlando, Florida, United States
Recruiting
Orlando Health Orlando Regional Medical Center
Orlando, Florida, United States
Recruiting
BRCR Global - Tamarac
Tamarac, Florida, United States
Recruiting
Hackensack University Medical Center
Hackensack, New Jersey, United States
Recruiting
John Theurer Cancer Center at Hackensack University Medical Center
Hackensack, New Jersey, United States
Recruiting
John Theurer Cancer Center at JSUMC
Neptune City, New Jersey, United States
Recruiting
Montefiore Medical Center- Montefiore Medical Park
The Bronx, New York, United States
Recruiting
Oncology Associates of Oregon, P.C.
Eugene, Oregon, United States
Recruiting
Dallas Cancer Specialists
Garland, Texas, United States
Recruiting
Southwest Oncology Associates
Houston, Texas, United States
Recruiting
Lumi Research
Houston, Texas, United States
Recruiting
US Oncology Investigational Products Center (IPC)
Irving, Texas, United States
Recruiting
Voyage Clinical
Sugar Land, Texas, United States
Recruiting
VCU Medical Center Gateway Building
Richmond, Virginia, United States
Recruiting
Virginia Commonwealth University
Richmond, Virginia, United States
Recruiting
VCU Health Stony Point
Richmond, Virginia, United States
Recruiting
Massey Cancer Center Clinical & Translational Research Lab
Richmond, Virginia, United States
Recruiting
Virginia Commonwealth University
Richmond, Virginia, United States
Recruiting
VCU Health Community Memorial Hospital
South Hill, Virginia, United States
Recruiting
VCU Health Tappahannock Hospital
Tappahannock, Virginia, United States
Recruiting
Beijing Cancer hospital
Beijing, Beijing Municipality, China
Recruiting
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China
Recruiting
Fujian Cancer Hospital
Fuzhou, Fujian, China
Recruiting
Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology
Wuhan, Hubei, China
Not yet recruiting
Jiangsu Province Hospital
Nanjing, Jiangsu, China
Not yet recruiting
Shanghai Chest Hospital
Shanghai, Shanghai Municipality, China
Recruiting
Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, China
Not yet recruiting
Taizhou Hospital of Zhejiang Province
Taizhou, Zhejiang, China
Recruiting
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest
Bordeaux, Aquitaine, France
Recruiting
Centre Georges François Leclerc
Dijon, CÔTE D'OR, France
Recruiting
Institut Paoli-Calmettes
Marseille, Provence-Alpes-Côte d'Azur Region, France
Recruiting
Groupe hospitalier Paris saint Joseph
Paris, Île-de-France Region, France
Not yet recruiting
Universitaetsklinikum Freiburg
Freiburg im Breisgau, Baden-Wurttemberg, Germany
Recruiting
Krankenhaus Nordwest GmbH
Frankfurt am Main, Hesse, Germany
Recruiting
Marien Hospital Düsseldorf
Düsseldorf, North Rhine-Westphalia, Germany
Recruiting
Azienda Sanitaria Territoriale Pesaro Urbino (AST PU)
Fano, Pesaro AND Urbino, Italy
Not yet recruiting
IRCCS Istituto Nazionale dei Tumori Regina Elena
Roma, ROME, Italy
Not yet recruiting
Ospedale Isola Tiberina - Gemelli Isola
Roma, ROME, Italy
Not yet recruiting
National Cancer Center Hospital East
Kashiwa, Chiba, Japan
Not yet recruiting

Showing 60 of 90 sites — filter to narrow it down. 79 of the 90 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT07227298. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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