Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke
Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke - a Randomized Clinical Trial
- Arterial Ischemic Stroke
At a glance
- Phase
- Phase not stated
- Study type
- Interventional
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
- Enrolment target
- 1,300
- Started
- 4 June 2025
- Main results due
- December 2026
- Study sites
- 7
- Registry updated
- 29 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Patients diagnosed with ischemic stroke aged 18 years or older; * Ability to undergo carotid and transcranial Doppler ultrasound, as well as to mobilize within 48 hours; * Informed consent obtained from the patient or legal representative. Exclusion Criteria: * Pre-existing disability with a modified Rankin Scale (mRS) score ≥ 4; * Diagnosis of Transient Ischemic Attack (TIA); * Severe hemodynamic instability, defined as: * Systolic blood pressure \< 100 mmHg or \> 220 mmHg; * Peripheral oxygen saturation \< 92%; * Heart rate \< 40 or \> 112 beats per minute; * Body temperature \> 38.5°C; * Neurological deterioration with altered level of consciousness (defined as Glasgow Coma Scale \< 10); * Patients who underwent neurosurgical intervention within the past 30 days; * Concomitant diagnosis of a rapidly progressive fatal disease (e.g., terminal-stage cancer); * Requirement for continuous monitoring or continuous intravenous drug infusion; * Acute deep vein thrombosis/pulmonary embolism.
What this study is about
In the sponsor’s own words, from the registry.
Post-stroke mobilization remains a subject of ongoing debate. While early mobilization-particularly the first out-of-bed mobilization-has been associated with reduced systemic complications and earlier rehabilitation, it also carries potential risks, such as neurological deterioration in the presence of hemodynamic instability.
In this study, the primary aim is to investigate whether early mobilization, guided by hemodynamic evaluation after acute ischemic stroke offers superior outcomes compared to standard clinical care.
Study sites(7)
University Hospital Rijeka
Rijeka, Croatia
Not yet recruiting
University Hospital Center Zagreb
Zagreb, Croatia
Not yet recruiting
Unidade Local de Saude de Coimbra
Coimbra, Coimbra District, Portugal
Recruiting
Unidade Local de Saúde de Santa Maria
Lisbon, Lisbon District, Portugal
Not yet recruiting
Unidade Local de Saude de Matosinhos
Porto, Matosinhos, Portugal
Recruiting
Unidade Local de Saúde de São João
Porto, Porto District, Portugal
Not yet recruiting
ULS São José
Lisbon, Portugal
Recruiting
Showing 7 of 7 sites. 3 of the 7 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07232498. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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