The EDC is live today — see what ships now
All studies
NCT07232498From ClinicalTrials.govRecruiting

Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke

Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke - a Randomized Clinical Trial

  • Arterial Ischemic Stroke

At a glance

Phase
Phase not stated
Study type
Interventional
Sponsor
Unidade Local de Saúde de Coimbra, EPE
Enrolment target
1,300
Started
4 June 2025
Main results due
December 2026
Study sites
7
Registry updated
29 September 2026

Can you take part?

  • Aged 18 years and over.
  • Open to any sex.
  • You need the condition being studied — healthy volunteers are not accepted.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria
Inclusion Criteria:

* Patients diagnosed with ischemic stroke aged 18 years or older;
* Ability to undergo carotid and transcranial Doppler ultrasound, as well as to mobilize within 48 hours;
* Informed consent obtained from the patient or legal representative.

Exclusion Criteria:

* Pre-existing disability with a modified Rankin Scale (mRS) score ≥ 4;
* Diagnosis of Transient Ischemic Attack (TIA);
* Severe hemodynamic instability, defined as:
* Systolic blood pressure \< 100 mmHg or \> 220 mmHg;
* Peripheral oxygen saturation \< 92%;
* Heart rate \< 40 or \> 112 beats per minute;
* Body temperature \> 38.5°C;
* Neurological deterioration with altered level of consciousness (defined as Glasgow Coma Scale \< 10);
* Patients who underwent neurosurgical intervention within the past 30 days;
* Concomitant diagnosis of a rapidly progressive fatal disease (e.g., terminal-stage cancer);
* Requirement for continuous monitoring or continuous intravenous drug infusion;
* Acute deep vein thrombosis/pulmonary embolism.

What this study is about

In the sponsor’s own words, from the registry.

Post-stroke mobilization remains a subject of ongoing debate. While early mobilization-particularly the first out-of-bed mobilization-has been associated with reduced systemic complications and earlier rehabilitation, it also carries potential risks, such as neurological deterioration in the presence of hemodynamic instability.

In this study, the primary aim is to investigate whether early mobilization, guided by hemodynamic evaluation after acute ischemic stroke offers superior outcomes compared to standard clinical care.

Study sites(7)

  • University Hospital Rijeka

    Rijeka, Croatia

    Not yet recruiting

  • University Hospital Center Zagreb

    Zagreb, Croatia

    Not yet recruiting

  • Unidade Local de Saude de Coimbra

    Coimbra, Coimbra District, Portugal

    Recruiting

  • Unidade Local de Saúde de Santa Maria

    Lisbon, Lisbon District, Portugal

    Not yet recruiting

  • Unidade Local de Saude de Matosinhos

    Porto, Matosinhos, Portugal

    Recruiting

  • Unidade Local de Saúde de São João

    Porto, Porto District, Portugal

    Not yet recruiting

  • ULS São José

    Lisbon, Portugal

    Recruiting

Showing 7 of 7 sites. 3 of the 7 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT07232498. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

Not the right study?

Answer three questions and see the studies recruiting near you, in plain language.

Find a study for me
Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke | Trialion