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NCT07254234From ClinicalTrials.govRecruiting

A Study of Retinal Imaging to Detect Abnormal Protein Deposits Associated With Alzheimer's Disease

Exploratory Study to Assess Utility of RetiSpec Artificial Intelligence Powered Retinal Imaging Solution in Detecting Amyloid Pathology in United Arab Emirates Nationals With Mild Impairment of Cognition

  • Cognitive Dysfunction
  • Memory Disorders

At a glance

Phase
Phase not stated
Study type
Observational
Sponsor
Eli Lilly and Company
Enrolment target
200
Started
23 September 2026
Main results due
September 2027
Study sites
3
Registry updated
24 September 2026

Can you take part?

  • Aged 55 years and over.
  • Open to any sex.
  • You need the condition being studied — healthy volunteers are not accepted.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria
Inclusion Criteria:

* Participants who are overtly healthy as determined by medical evaluation, including medical history and physical examination.
* Have mild memory complaints or a diagnosis of mild cognitive impairment.
* Have undergone genotyping for apolipoprotein E (APOE) and are willing to make results available to the investigator.
* Montreal Cognitive Assessment (MoCA) score of greater than or equal to 22 and less than or equal to 28.

Exclusion Criteria:

* Have any medical condition that, in the opinion of the investigator, would be a contraindication to participation in the study.
* Have an existing diagnosis of AD or other dementia.
* Have contradictions to or an allergy to the ophthalmic dilating agents.
* Have known diagnosis of severe glaucoma or severe cataracts; have a significant refractive error (more than 12 diopters \[D\] of spherical equivalent refraction); or have any ocular media opacity that prevents imaging of the retina (that is, severe cataract). Note: mild to moderate cataracts or vision correction with glasses or contact lenses are not exclusion criteria.
* Current or previous treatment with anti-amyloid medications.
* Are currently enrolled in any other clinical study involving an investigational product or any other type of medical research judged not to be scientifically or medically compatible with this study.

What this study is about

In the sponsor’s own words, from the registry.

The purpose of this study is to test the use of a screening tool to detect changes in the eye that are associated with Alzheimer's disease in adult participants with memory issues. For each participant, the study will last up to one month and requires one visit to the research site.

Study sites(3)

  • Burjeel Medical City

    Abu Dhabi, United Arab Emirates

    Not yet recruiting

  • Sheikh Shakhbout Medical City

    Abu Dhabi, United Arab Emirates

    Recruiting

  • Sheikh Tahnoon Bin Mohammed Medical City

    Abu Dhabi, United Arab Emirates

    Recruiting

Showing 3 of 3 sites. 2 of the 3 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT07254234. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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A Study of Retinal Imaging to Detect Abnormal Protein Deposits Associated With Alzheimer's Disease | Trialion