A Study to Evaluate the Efficacy and Safety of JNJ-88545223 for the Treatment of Participants With Active Psoriatic Arthritis
A Phase 2b, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of JNJ-88545223 For the Treatment of Participants With Active Psoriatic Arthritis
- Arthritis, Psoriatic
At a glance
- Phase
- Phase 2
- Study type
- Interventional
- Sponsor
- Janssen Research & Development, LLC
- Enrolment target
- 240
- Started
- 15 January 2026
- Main results due
- 28 June 2027
- Study sites
- 75
- Registry updated
- 25 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Have a diagnosis of psoriatic arthritis (PsA) for at least 3 months before the first administration of study intervention and meet classification criteria for Psoriatic Arthritis (CASPAR) at screening * Have active PsA as defined by: (a) At least 3 swollen joints and at least 3 tender joints at screening and at baseline (Week 0/Day 1) based on the 66/68 joint assessment; AND (b) C-reactive protein (CRP) greater than or equal to (\>=) 0.1 milligrams per deciliter (mg/dL) at screening from the central laboratory * Have \>= 1 of the following PsA subsets: distal interphalangeal joint involvement, polyarticular arthritis with absence of rheumatoid nodules, asymmetric peripheral arthritis, or spondylitis with peripheral arthritis * Have active plaque psoriasis with at least one psoriatic plaque of \>= 2 centimeter (cm) diameter or nail changes consistent with psoriasis * A female participant of childbearing potential must have a negative highly sensitive serum pregnancy test (Beta-hCG) at screening and a negative urine pregnancy test at Week 0 prior to administration of study intervention Exclusion Criteria: * Has a nonplaque form of psoriasis (for example, erythrodermic, guttate, or pustular) * Has a history or current signs or symptoms of severe, progressive, or uncontrolled renal, hepatic, cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic, hematologic, rheumatologic (except PsA), psychiatric, genitourinary, or metabolic disturbances * Has suspected or known allergies, hypersensitivity, or intolerance to JNJ-88545223 or excipients used in the investigational medicinal product (IMP), including placebo (JNJ-88545223 investigator's brochure); or has a history of severe allergic reaction, angioedema, or anaphylaxis to drugs or food * Has fibromyalgia or osteoarthritis symptoms that, in the opinion of the investigator, would have potential to interfere with efficacy assessments * Currently has a malignancy or has a history of malignancy within 5 years prior to screening
What this study is about
In the sponsor’s own words, from the registry.
The purpose of this study is to evaluate how well the study drug JNJ-88545223 works compared with a placebo (an inactive substance) in adults with active psoriatic arthritis (PsA). The study aims to see whether treatment with JNJ-88545223 can help reduce the signs and symptoms of PsA and improve joint and skin health.
Study sites(75)
Unity Health-White County Medical Center
Searcy, Arkansas, United States
Recruiting
Newport Huntington Medical Group
Huntington Beach, California, United States
Recruiting
Rheumatology Center of San Diego
San Diego, California, United States
Recruiting
Clinical Research of West Florida 1
Clearwater, Florida, United States
Recruiting
American Research, LLC
Cutler Bay, Florida, United States
Recruiting
Innovation Medical Research Center
Palmetto Bay, Florida, United States
Recruiting
Integral Rheumatology And Immunology Specialists
Plantation, Florida, United States
Recruiting
Clinical Research of West Florida
Tampa, Florida, United States
Recruiting
Conquest Research
Winter Park, Florida, United States
Recruiting
Atlanta Research Center for Rheumatology
Marietta, Georgia, United States
Recruiting
Willow Rheumatology and Wellness PLLC
Willowbrook, Illinois, United States
Recruiting
Qualmedica Research
Evansville, Indiana, United States
Recruiting
Albuquerque Rehabilitation and Rheumatology
Albuquerque, New Mexico, United States
Recruiting
Joint and Muscle Research Institute
Charlotte, North Carolina, United States
Recruiting
Onsite Clinical Solutions
Salisbury, North Carolina, United States
Recruiting
Paramount Medical Research & Consulting
Middleburg Heights, Ohio, United States
Recruiting
Clinical Research Philadelphia
Philadelphia, Pennsylvania, United States
Recruiting
Arthritis and Rheumatology Research Institute
Frisco, Texas, United States
Recruiting
Peking University People's Hospital
Beijing, China
Recruiting
Peking University Third Hospital
Beijing, China
Recruiting
Beijing Tsinghua Changgung Hospital
Beijing, China
Recruiting
Xiangya Hospital Central South University
Changsha, China
Recruiting
Changzhou No 2 Peoples Hospital
Changzhou, China
Recruiting
West China Hospital Sichuan University
Chengdu, China
Recruiting
The First Affiliated Hospital of Chongqing Medical University
Chongqing, China
Recruiting
The Second Affiliated Hospital of Zhejiang University
Hangzhou, China
Recruiting
Ningbo medical center lihuili hospital
Ningbo, China
Recruiting
Shanghai Sixth People's Hospital
Shanghai, China
Recruiting
RHEUMA s r o
Břeclav, Czechia
Recruiting
L K N Arthrocentrum
Hlučín, Czechia
Recruiting
Revmatologicka ambulance
Karvina Frystat, Czechia
Recruiting
Pratia Czech A S
Pardubice, Czechia
Recruiting
Clintrial s r o
Prague, Czechia
Recruiting
Medical Plus Research S R O
Uherské Hradiště, Czechia
Recruiting
Fachklinik Bad Bentheim
Bad Bentheim, Germany
Recruiting
Charite Universitaetsmedizin Berlin
Berlin, Germany
Recruiting
Rheumatologische Schwerpunktpraxis
Berlin, Germany
Recruiting
Praxis Mario Sutowicz
Cottbus, Germany
Recruiting
Hamburger Rheuma Forschungszentrum II
Hamburg, Germany
Recruiting
CAIR Heidelberg
Heidelberg, Germany
Recruiting
Gemeinschaftspraxis Dres. Quist
Mainz, Germany
Recruiting
Hautarztpraxis Mortazawi
Remscheid, Germany
Recruiting
Hautarztpraxis
Witten, Germany
Recruiting
Semmelweis Egyetem Reumatologiai es Immunologiai Klinika
Budapest, Hungary
Recruiting
Obudai Egeszsegugyi Centrum Kft
Budapest, Hungary
Recruiting
Qualiclinic Kft
Budapest, Hungary
Recruiting
Bekes Varmegyei Kozponti Korhaz Pandy Kalman Tagkorhaz
Gyula, Hungary
Recruiting
Porcika Klinika - Vasarhelyi Sarkanyfu Kft.
Hódmezővásárhely, Hungary
Recruiting
Complex Rendelo Med Zrt
Székesfehérvár, Hungary
Recruiting
Vital Medical Center Orvosi es Fogaszati Kozpont
Veszprém, Hungary
Recruiting
Tokyo Metropolitan Tama Medical Center
Fuchū, Japan
Recruiting
Imamura General Hospital
Kagoshima, Japan
Recruiting
Hospital of the University of Occupational and Environmental Health
Kitakyushu-shi, Japan
Recruiting
Osaka Metropolitan University Hospital
Osaka, Japan
Recruiting
Sanuki Municipal Hospital
Sanuki, Japan
Recruiting
Tokito Clinic Rheumatology and Orthopaedic Surgery
Shimonoseki, Japan
Recruiting
Nzoz Osteo Medic
Bialystok, Poland
Recruiting
Szpital Uniwersytecki nr 2 im dr Jana Biziela w Bydgoszczy
Bydgoszcz, Poland
Recruiting
Centrum Kliniczno Badawcze
Elblag, Poland
Recruiting
Malopolskie Badania Kliniczne Sp z o o
Krakow, Poland
Recruiting
Showing 60 of 75 sites — filter to narrow it down. 75 of the 75 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07321873. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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