Transcatheter Tricuspid Valve Replacement With the Medtronic Intrepid™ Transcatheter Tricuspid Valve Replacement (TTVR) System in Severe Tricuspid Regurgitation
Transcatheter Tricuspid Valve Replacement Using the Medtronic Intrepid™ TTVR System in Patients With Severe Symptomatic Tricuspid Regurgitation - PATHFINDER
- Severe Tricuspid Regurgitation
At a glance
- Phase
- Phase not stated
- Study type
- Interventional
- Sponsor
- Medtronic Cardiovascular
- Enrolment target
- 1,186
- Started
- 11 September 2026
- Main results due
- September 2031
- Study sites
- 13
- Registry updated
- 25 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Age ≥18 years at the time of consent. * Severe symptomatic tricuspid regurgitation (TR) despite optimal medical therapy (OMT). * Local site multidisciplinary heart team experienced in tricuspid valve therapies agrees that the subject is appropriate for TTVR. Exclusion Criteria: * Any tricuspid device currently in place. * Anatomic contraindications. * Need for emergent or urgent surgery. * Left ventricular ejection fraction \<25%.
What this study is about
In the sponsor’s own words, from the registry.
This clinical trial evaluates the safety and effectiveness of the Medtronic Intrepid™ Transcatheter Tricuspid Valve Replacement (TTVR) System in symptomatic patients with severe or greater tricuspid regurgitation.
Study sites(13)
University of Alabama at Birmingham (UAB) Hospital
Birmingham, Alabama, United States
Recruiting
Abrazo Arizona Heart Hospital
Phoenix, Arizona, United States
Recruiting
Los Robles Hospital & Medical Center
Thousand Oaks, California, United States
Recruiting
Yale New Haven Hospital
New Haven, Connecticut, United States
Recruiting
Emory University Hospital Midtown
Atlanta, Georgia, United States
Recruiting
Northwestern Memorial Hospital
Chicago, Illinois, United States
Recruiting
Abbott Northwestern Hospital
Minneapolis, Minnesota, United States
Recruiting
Buffalo General Medical Center
Buffalo, New York, United States
Recruiting
Northwell Health North Shore University Hospital
Manhasset, New York, United States
Recruiting
NYU Langone Medical Center
New York, New York, United States
Recruiting
Montefiore Medical Center
New York, New York, United States
Recruiting
The Christ Hospital
Cincinnati, Ohio, United States
Recruiting
Cleveland Clinic Foundation
Cleveland, Ohio, United States
Recruiting
Showing 13 of 13 sites. 13 of the 13 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07321899. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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