AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight
Efficacy and Safety of NNC0487-0111 s.c. Once-weekly in Participants With Obesity (AMAZE 1)
- Obesity
At a glance
- Phase
- Phase 3
- Study type
- Interventional
- Sponsor
- Novo Nordisk A/S
- Enrolment target
- 1,150
- Started
- 24 February 2026
- Main results due
- 26 June 2029
- Study sites
- 72
- Registry updated
- 24 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Key Inclusion Criteria: * Male or female (sex at birth). * Informed consent obtained before any study-related activities. Study-related activities are any procedures that are carried out as part of the study, including activities to determine suitability for the study. * History of at least one self-reported unsuccessful dietary effort to lose body weight. Key Exclusion Criteria: * HbA1c ≥ 6.5% (48 millimole per mole \[mmol/mol\]) as measured by the central laboratory at screening. * History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records. * Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening.
What this study is about
In the sponsor’s own words, from the registry.
The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.
Study sites(72)
South Broward Research LLC
Miramar, Florida, United States
Recruiting
Clinical Neuroscience Solution
Orlando, Florida, United States
Recruiting
Hope Clin Res & Wellness
Conyers, Georgia, United States
Recruiting
Endeavor Health
Skokie, Illinois, United States
Recruiting
Midwest Inst For Clin Res
Indianapolis, Indiana, United States
Recruiting
StudyMetrix Research LLC
City of Saint Peters, Missouri, United States
Recruiting
New York Gastroenterology Associates
New York, New York, United States
Recruiting
UNC Eastowne Medical Office
Chapel Hill, North Carolina, United States
Recruiting
PharmQuest Life Sciences LLC
Greensboro, North Carolina, United States
Recruiting
Accellacare and KDCILM, LLC
Wilmington, North Carolina, United States
Recruiting
UPA Ctr Weight and Eating Dis
Philadelphia, Pennsylvania, United States
Recruiting
Clinical Res Collaborative
Cumberland, Rhode Island, United States
Recruiting
Medical Uni of SC Charleston
Charleston, South Carolina, United States
Recruiting
Coastal Carolina Research Ctr
North Charleston, South Carolina, United States
Recruiting
Hillcrest Clinical Research
Simpsonville, South Carolina, United States
Recruiting
Amarillo Medical Specialists
Amarillo, Texas, United States
Recruiting
Velocity Clinical Res-Dallas
Dallas, Texas, United States
Recruiting
Care United Research, LLC
Forney, Texas, United States
Recruiting
Washington Cntr Weight Mgmt
Arlington, Virginia, United States
Recruiting
Health Res of Hampton Roads
Newport News, Virginia, United States
Recruiting
Selma Medical Associates
Winchester, Virginia, United States
Recruiting
Rainier Clin Res Ctr Inc
Renton, Washington, United States
Recruiting
Fundación CESIM
Santa Rosa, La Pampa Province, Argentina
Recruiting
Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli
Buenos Aires, Argentina
Recruiting
Instituto de Investigaciones Clínicas Córdoba
Córdoba, Argentina
Recruiting
Sanatorio Esperanza
Esperanza, Santa Fe, Argentina
Recruiting
CIPADI
Godoy Cruz, Argentina
Recruiting
Instituto de Investigaciones Clinicas San Nicolás
San Nicolás, Argentina
Recruiting
Sydney Clinical Trials
Campbelltown, New South Wales, Australia
Recruiting
Sydney Cardiometabolic Centre
Liverpool, New South Wales, Australia
Recruiting
Hunter Diabetes Centre
Merewether, New South Wales, Australia
Recruiting
Heart of Australia
Chelmer, Queensland, Australia
Recruiting
HUB - Hôpital Erasme
Brussels, Belgium
Recruiting
UZA - UZ Antwerpen - Department of Endocrinology
Edegem, Belgium
Recruiting
Universitair Ziekenhuis Gent
Ghent, Belgium
Recruiting
UZ Leuven - Endocrinology
Leuven, Belgium
Recruiting
MECLINAS
Mechelen, Belgium
Recruiting
AZ Delta - Roeselare
Roeselare, Belgium
Recruiting
C-Health Partners
Calgary, Alberta, Canada
Recruiting
Ocean West Research Clinic
Surrey, British Columbia, Canada
Recruiting
G.A. Research Associates Ltd.
Moncton, New Brunswick, Canada
Recruiting
Nova Scotia Hlth Halifax
Halifax, Nova Scotia, Canada
Recruiting
Milestone Research
London, Ontario, Canada
Recruiting
Sanos Clinic - Vejle
Vejle, Region Syddanmark, Denmark
Recruiting
Sanos Clinic - Gandrup
Gandrup, Denmark
Recruiting
Steno Diabetes Center Nordjylland
Gistrup, Denmark
Completed
Gentofte Hospital - Center for Klinisk Metabolisk Forskning
Hellerup, Denmark
Recruiting
Hillerød Endokrinologisk amb. H0652
Hillerød, Denmark
Recruiting
Hvidovre Hospital Endokrinologisk forsknings afsnit 159
Hvidovre, Denmark
Recruiting
HOPITAL EUROPEEN GEORGES POMPIDOU_Service de nutrition et diabétologie
Paris, France
Recruiting
HCL-HOPITAL LYON SUD_Service d'Endocrinologie-Diabète-Nutrition
Pierre-Bénite, France
Recruiting
CHU NANTES - HOPITAL NORD LAENNEC_Service d'Endocrinologie-Diabétologie-Nutrition
Saint-Herblain, France
Recruiting
CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE-HOPITAL RANGUEIL-Service de diabétologie et nutrition
Toulouse, France
Recruiting
CENTRE DE RECHERCHE CLINIQUE PORTES DU SUD_Service d'Endocrinologie-Diabétologie-Maladies Métaboliques
Vénissieux, France
Recruiting
Herz- und Diabeteszentrum NRW - Bad Oeynhausen
Bad Oeynhausen, Germany
Active, not recruiting
Zentrum für klinische Studien Südbrandenburg GmbH
Elsterwerda, Germany
Active, not recruiting
MVZ im Altstadt-Carree Fulda GmbH - Zentrum für klinische Studien
Fulda, Germany
Active, not recruiting
SMO.MD GmbH - Zentrum für klinische Studien
Magdeburg, Germany
Active, not recruiting
Institut für Diabetesforschung Osnabrück
Osnabrück, Germany
Active, not recruiting
Forschungszentrum Ruhr KliFoCenter GmbH, Kahrmann
Witten, Germany
Active, not recruiting
Showing 60 of 72 sites — filter to narrow it down. 65 of the 72 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07339423. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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