Postoperative Acute Kidney Injury in Children Undergoing Major Non-cardiac Surgery
An International Multicentre Prospective Study of Postoperative Acute Kidney Injury in Hospitalized Paediatric Patients
- Acute Kidney Injury
At a glance
- Phase
- Phase not stated
- Study type
- Observational
- Sponsor
- Uppsala University
- Enrolment target
- 2,000
- Started
- 1 March 2026
- Main results due
- 31 December 2028
- Study sites
- 16
- Registry updated
- 29 September 2026
Can you take part?
- Ages 0 years to 16 years.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Elective, urgent or emergency in-patient major non-cardiac surgical procedures performed under general anaesthesia with or without regional analgesia with a planned procedure duration of at least 60 minutes. * Paediatric patients (0-16 years old) Exclusion Criteria: * Declined participation. * Ongoing renal replacement therapy * Acute Kidney Injury (according to KDIGO) * Known chronic kidney disease * Procedure involving surgery of the kidney * Procedures requiring clamping of blood flow to or from the kidney * Body weight \<2kg * Procedure involving contrast administration * Established rhabdomyolysis (CK-levels \>1500 U/L)
What this study is about
In the sponsor’s own words, from the registry.
This project aims to conduct an international, prospective, multicentre, observational study to determine the incidence of Postoperative Acute Kidney Injury (PO-AKI) in hospitalized children after noncardiac surgery. Urinary biomarkers are intended to be evaluated as predictors of PO-AKI in the same subjects. The study employs modern standardized classifications for AKI to comprehensively address the issue of PO-AKI in children. Describing the incidence and identifying risk factors for PO-AKI will play a crucial role in developing preventive strategies aimed at reducing associated mortality and morbidity. Furthermore, investigating the relationship between urinary biomarkers of renal injury and PO-AKI will provide valuable insights into assessing postoperative renal function in paediatric patients, especially when repeated blood sampling is not feasible.
Study sites(16)
Perth Children's Hospital
Perth, Western Australia, Australia
Not yet recruiting
The Kids Research Institute Australia
Perth, Western Australia, Australia
Not yet recruiting
Hospital das Clínicas HCFMUSP
São Paulo, Brazil
Recruiting
Montreal Children's Hospital
Montreal, Quebec, Canada
Not yet recruiting
Children's Hospital Zagreb
Zagreb, Croatia
Not yet recruiting
Hospices Civils de Lyon
Lyon, France
Not yet recruiting
IRCCS Istituto Giannina Gaslini
Genova, Italy
Recruiting
Radboud UMC
Nijmegen, Netherlands
Not yet recruiting
University Hospital of Belgrade
Belgrade, Serbia
Recruiting
Sahlgrenska University Hospital
Gothenburg, Sweden
Recruiting
Skåne University Hospital
Lund, Sweden
Not yet recruiting
Karolinska University Hospital
Stockholm, Sweden
Recruiting
Uppsala University Hospital
Uppsala, Sweden
Recruiting
University Hospital Basel
Basel, Switzerland
Not yet recruiting
University Hospital Bern
Bern, Switzerland
Not yet recruiting
University Hospital Geneva
Geneva, Switzerland
Not yet recruiting
Showing 16 of 16 sites. 6 of the 16 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07351149. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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