NCT07376889From ClinicalTrials.govRecruiting

Combination Antibiotic Therapy for Staphylococcus Aureus Bacteremia

COMBAT-SAB: Combination Antibiotic Therapy for Staphylococcus Aureus Bacteremia

Staphylococcus Aureus Bacteremia

At a glance

Phase: Phase 4
Study type: Interventional
Sponsor: Intermountain Health Care, Inc.
Enrolment target: 2,096
Started: 1 February 2026
Main results due: January 2029
Study sites: 13
Registry updated: 25 September 2026

Can you take part?

Aged 18 years and over.
Open to any sex.
You need the condition being studied — healthy volunteers are not accepted.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria

Inclusion Criteria:

* Age ≥18 years
* Alive and admitted to an Intermountain Health (IH) hospital acute care unit at enrollment
* Initial positive blood culture with either methicillin-resistant Staphylococcus aureus (MRSA) or methicillin-susceptible Staphylococcus aureus (MSSA), collected:

  1. on or during the index admission to an IH hospital, or
  2. in an ambulatory setting (laboratory, clinic or emergency department) within 48 hours of the index admission, or
  3. at a non-IH network hospital within 24 hours of subsequent transfer to an IH hospital

     Exclusion Criteria:
* Patient requests that patient health data not be included in the analysis

What this study is about

In the sponsor’s own words, from the registry.

The purpose of this study is to see if, in selected patients with a serious bacterial infection of the bloodstream, treating the bacterial infection with a combination of antibiotics is more effective than treating the infection with a single antibiotic. Participants must have blood cultures which are positive for a certain type of bacteria.

Study sites(13)

Platte Valley Hospital
Brighton, Colorado, United States
Recruiting
Saint Joseph Hospital
Denver, Colorado, United States
Recruiting
St. Mary's Regional Hospital
Grand Junction, Colorado, United States
Recruiting
Good Samaritan Hospital
Lafayette, Colorado, United States
Recruiting
Lutheran Medical Center
Wheat Ridge, Colorado, United States
Recruiting
St. Vincent Regional Hospital
Billings, Montana, United States
Recruiting
St. James Hospital
Butte, Montana, United States
Recruiting
Holy Rosary Hospital
Miles City, Montana, United States
Recruiting
Intermountain Medical Center
Murray, Utah, United States
Recruiting
McKay-Dee Hospital
Ogden, Utah, United States
Recruiting
Utah Valley Hospital
Provo, Utah, United States
Recruiting
LDS Hospital
Salt Lake City, Utah, United States
Recruiting
St. George Regional Hospital
St. George, Utah, United States
Recruiting

Showing 13 of 13 sites. 13 of the 13 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT07376889. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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