Markers of Bone Destruction and Oxidative Stress in Peri-implantitis
Evaluation of Bone Destruction and Oxidative Stress Markers in Saliva and Peri-implant Sulcus Fluid in Peri-implantitis
- Periodontal Diseases
- Periimplant Diseases
At a glance
- Phase
- Phase not stated
- Study type
- Observational
- Sponsor
- Saglik Bilimleri Universitesi
- Enrolment target
- 80
- Started
- 15 February 2026
- Main results due
- 15 November 2026
- Study sites
- 1
- Registry updated
- 29 September 2026
Can you take part?
- Ages 18 years to 65 years.
- Open to any sex.
- Healthy volunteers can take part.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: Systemically healthy volunteers aged 18-65. For Peri-implantitis group: Implants in function for ≥1 year, radiographic bone loss ≥ 2 mm, probing depth (PD) ≥ 5 mm, and presence of bleeding on probing (BOP) or suppuration. For Periodontitis group: At least one tooth with PD ≥ 4 mm, presence of BOP, and radiographic bone loss.For Healthy groups: PD ≤ 3 mm, no clinical inflammation (BOP-), and no radiographic bone loss. (According to the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases) - Exclusion Criteria:Presence of systemic diseases (e.g., diabetes, rheumatoid arthritis, osteoporosis). Use of antibiotics, anti-inflammatory, or immunosuppressive drugs within the last 3 months. Pregnancy or breastfeeding. Smoking (current smokers). History of periodontal or peri-implant surgical treatment within the last 6 months. Implant failure (mobility). Signs of acute infection (fever, systemic symptoms). \-
What this study is about
In the sponsor’s own words, from the registry.
The aim of this study is to evaluate and compare the levels of bone resorption (RANKL, OPG) and oxidative stress (Nitrotyrosine, NQO1) markers, along with pro-inflammatory cytokines (IL-1β), in the saliva and peri-implant sulcular fluid (PISF) of patients with peri-implantitis, periodontitis, and healthy individuals. The study seeks to determine the diagnostic value of these biomarkers in the early detection and progression of peri-implant diseases.
Study sites(1)
Gülhane Faculty of Dentistry, University of Health Sciences
Keçiören, Ankara, Turkey (Türkiye)
Recruiting
Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07397884. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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