A Study of TORL-5-700 in Relapsed/Refractory Non Hodgkin's Lymphoma
A Phase 1/2, First-in-Human, Open-Label, Multicenter Study of TORL-5-700 as a Monotherapy and in Combination for Participants With Relapsed or Refractory Non-Hodgkin Lymphoma
- Histologically Confirmed Relapsed or Refractory B-cell Non-Hodgkin Lymphoma
At a glance
- Phase
- Phase 1
- Study type
- Interventional
- Sponsor
- TORL Biotherapeutics, LLC
- Enrolment target
- 155
- Started
- 31 March 2026
- Main results due
- 31 March 2029
- Study sites
- 9
- Registry updated
- 28 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Confirmed B-NHL, including but not limited to de novo DLBCL; FL, Grades 1 to 3A; MCL; transformed lymphoma (tFL, RT) and FL Grade 3B; MZL and MALT. * Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to 2. * At least 1 measurable lesion per Lugano criteria. * Tumor tissue is available. * Adequate organ function Exclusion Criteria: * T-cell lymphoma * CLL or SL * Burkitt lymphoma and high-grade B-cell lymphoma * CNS involvement * Peripheral neuropathy \> Grade 2 * Uncontrolled medical conditions * Viral infections
What this study is about
In the sponsor’s own words, from the registry.
A Phase 1/2 study to evaluate safety, tolerability, and anticancer activity of TORL-5-700 as a monotherapy and in combination in R/R NHL
Study sites(9)
Providence Medical Foundation
Fullerton, California, United States
Recruiting
Cancer and Blood Specialty Clinic, Los Alamitos
Los Alamitos, California, United States
Recruiting
UCLA
Santa Monica, California, United States
Recruiting
Stanford University
Stanford, California, United States
Recruiting
University of California Miami, Sylvester Comprehensive Cancer Center
Miami, Florida, United States
Recruiting
University of Iowa Health Care
Iowa City, Iowa, United States
Recruiting
Cancer Center of Kansas, Wichita
Wichita, Kansas, United States
Recruiting
Sarah Cannon Research Institute
Nashville, Tennessee, United States
Recruiting
University of Texas Southwestern Medical Center
Dallas, Texas, United States
Recruiting
Showing 9 of 9 sites. 9 of the 9 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07439653. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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