The Per-procedural Antibiotic Prophylaxis in Patients Undergoing Transcatheter Aortic Valve Implantation Trial
- Aortic Valve Stenosis
At a glance
- Phase
- Phase not stated
- Study type
- Interventional
- Sponsor
- Rigshospitalet, Denmark
- Enrolment target
- 1,986
- Started
- 1 October 2026
- Main results due
- 31 March 2029
- Study sites
- 5
- Registry updated
- 29 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * All patients \> 18 years of age undergoing TAVI at sites in Denmark Exclusion Criteria: * Patients who do not want to participate and have chosen to "opt-out" of the trial
What this study is about
In the sponsor’s own words, from the registry.
The study is a prospective, crossover, cluster randomized trial in patients undergoing transcatheter aortic valve implantation (TAVI). The study tests whether cephalosporin plus beta-lactam antibiotic with spectrum for Enterococcus faecalis as per procedural prophylaxis is superior to cephalosporin alone in reducing the composite outcome of bacteremia or death at 6 months post-TAVI.
Study sites(5)
Aalborg University Hospital
Aalborg, Denmark
Recruiting
Aarhus University Hospital
Aarhus, Denmark
Recruiting
Copenhagen University Hospital, Rigshospitalet
Copenhagen, Denmark
Recruiting
Odense University Hospital
Odense, Denmark
Recruiting
Skåne University Hospital Lund
Lund, Sweden
Not yet recruiting
Showing 5 of 5 sites. 4 of the 5 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07442357. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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