Enhancing Physical Reserve to Promote Resilience in Physically Frail Older Adults
Enhancing Physical Reserve to Promote Cognitive and Physical Resilience in Physically Frail Older Adults: A 3-Month Randomized Controlled Trial
- Frailty at Older Adults
At a glance
- Phase
- Phase not stated
- Study type
- Interventional
- Sponsor
- The Hong Kong Polytechnic University
- Enrolment target
- 224
- Started
- 19 January 2026
- Main results due
- 31 December 2028
- Study sites
- 1
- Registry updated
- 25 September 2026
Can you take part?
- Ages 60 years to 90 years.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: 1. are community-dwelling (i.e., not residing in a nursing home or extended care unit) ; 2. scored \< 9/12 on the SPPB; 3. scored \>18/30 on the MoCA; 4. are able to walk independently; use of walking aid is acceptable; 5. are able to safely engage in exercise as indicated by the Physical Activity Readiness Questionnaire Plus33 and confirmed by their physician; 6. have internet at home; and 7. are able to provide written informed consent. Exclusion Criteria: 1. diagnosed with dementia or stroke; 2. self-report engaging in strength and balance training exercises \> two-times-per-week in the 3 months prior to screening; 3. unable to understand, speak, and read Cantonese/Chinese/English proficiently; and 4. contraindications for MRI such as MRI-incompatible implants.
What this study is about
In the sponsor’s own words, from the registry.
The goal of this clinical trial is to assess the efficacy of combined aerobic and resistance training in enhancing physical reserve in older adults with physical frailty. Investigator contend that enhanced physical reserve will enable preservation of cognitive and physical function. The main questions aims to answer are: (1) Compared with usual care (i.e., CON), will 3-month aerobic and resistance training (ATRT) improve physical reserve in older adults with physical frailty? (2) Compared with CON, will ATRT lead to changes in the neural network organization? (3) Will improved physical reserve lead to better maintenance of cognitive and physical functioning in spite of presence of white matter hyperintensities (WMH)?
Study sites(1)
The Hong Kong Polytechnic University, Department of Rehabilitation Sciences
Hong Kong, Hong Kong, Hong Kong
Recruiting
Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07513701. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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