Multicomponent Prehabilitation in Older Adults With Breast Cancer
Multidimensional Oncogeriatric Prehabilitation in Older Adults With Breast Cancer: A Randomized Controlled Trial Integrating Frailty and Biomarker Assessment
- Breast Cancer
- Frailty
- Sarcopenia
- Aging
- Functional Decline
At a glance
- Phase
- Phase not stated
- Study type
- Interventional
- Sponsor
- Fundacion Miguel Servet
- Enrolment target
- 90
- Started
- 4 December 2024
- Main results due
- March 2027
- Study sites
- 1
- Registry updated
- 29 September 2026
Can you take part?
- Aged 65 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Age ≥65 years * Diagnosis of breast cancer requiring elective surgery with curative intent * Candidate for prehabilitation program before surgery * Ability to walk (with or without assistive devices) * Ability to provide informed consent Exclusion Criteria: * Urgent or emergency surgery * Severe cognitive impairment precluding participation in the intervention * Severe functional dependency (e.g., bedridden patients) * Medical contraindication to physical exercise * Life expectancy \<3 months
What this study is about
In the sponsor’s own words, from the registry.
Older adults with breast cancer frequently present with frailty, decreased functional reserve, and increased risk of postoperative complications. Prehabilitation programs have emerged as a promising strategy to improve physical function and clinical outcomes; however, evidence in geriatric oncology remains limited, particularly regarding the role of biological markers in predicting response to such interventions.
This study aims to evaluate the effectiveness of a multicomponent prehabilitation program in older adults with breast cancer, focusing on functional status, clinical outcomes, and quality of life. In addition, the study seeks to characterize biological markers associated with frailty and treatment response, with the goal of identifying potential predictors of benefit from prehabilitation.
Participants will undergo a structured prehabilitation intervention including physical exercise, nutritional optimization, and comprehensive geriatric assessment. Clinical, functional, and biomarker data will be collected longitudinally.
The results of this study may contribute to improving personalized care strategies in geriatric oncology and to identifying patients who are most likely to benefit from prehabilitation programs.
Study sites(1)
Hospital Universitario de Navarra
Pamplona, Navarre, Spain
Recruiting
Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07531836. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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