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NCT07564648From ClinicalTrials.govRecruiting

Impact of Novel vs. Usual Brand Menthol Cigarettes on Abuse Liability

  • Cigarette Addiction
  • Tobacco Use Disorder

At a glance

Phase
Phase not stated
Study type
Interventional
Sponsor
Ohio State University Comprehensive Cancer Center
Enrolment target
48
Started
18 August 2026
Main results due
30 September 2029
Study sites
1
Registry updated
24 September 2026

Can you take part?

  • Aged 21 years and over.
  • Open to any sex.
  • Healthy volunteers can take part.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria
Inclusion Criteria:

* Aged 21 years or older
* Currently smoke cigarettes daily (≥ 5 cigarettes/day) for at least the past 6 months, and their usual brand is menthol cigarettes
* Willing to provide informed consent
* Willing to abstain from all nicotine, tobacco, and smoked cannabis products for approximately 12 hours prior to each study visit
* Own and regularly use a functional smartphone compatible with study procedures (e.g., completing daily assessments)
* Willing to complete two weeks of daily assessments involving use of their usual brand menthol cigarettes and the study product
* Able to read, speak, and understand English

Exclusion Criteria:

* Current diagnosis of any significant lung diseases (e.g., asthma, chronic obstructive pulmonary disease, cystic fibrosis)
* History of a cardiac event or episode of cardiac distress (e.g., heart attack, hospitalization for chest pain) within the past 3 months
* Currently pregnant, planning to become pregnant during the study period, or currently breastfeeding
* Self-reported use of any non-cigarette nicotine or tobacco product (e.g., e-cigarettes, cigars, oral nicotine products) or cannabis on more than 10 days in the past 30 days
* Self-reported current participation in a smoking cessation program or intention to quit smoking in the next 3 months
* Self-reported difficulty with blood draws

What this study is about

In the sponsor’s own words, from the registry.

This randomized, double-blind, crossover human laboratory study compares the abuse liability of cigarettes containing menthol and non-menthol cigarette variants, using the participant's usual brand menthol cigarette as a within-subject reference. Participants complete standardized laboratory smoking sessions, behavioral economic tasks, and a naturalistic observational period. The study examines differences in nicotine delivery, smoking behavior, and subjective effects across cigarette types in laboratory and real-world contexts.

Study sites(1)

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, United States

    Recruiting

Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT07564648. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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Impact of Novel vs. Usual Brand Menthol Cigarettes on Abuse Liability | Trialion