Postoperative Pain and Substance P Levels After Bioceramic vs Calcium Hydroxide Intracanal Medicaments in Symptomatic Apical Periodontitis
Clinical Evaluation of the Postoperative Pain and Substance P Levels Following the Use of Bioceramic Verses Calcium Hydroxide Intracanal Medicaments in Permanent Mandibular Molars With Symptomatic Apical Periodontitis
- Symptomatic Apical Periodontitis
At a glance
- Phase
- Phase not stated
- Study type
- Interventional
- Sponsor
- Future University in Egypt
- Enrolment target
- 28
- Started
- 1 June 2026
- Main results due
- 1 February 2027
- Study sites
- 1
- Registry updated
- 25 September 2026
Can you take part?
- Ages 18 years to 45 years.
- Open to any sex.
- Healthy volunteers can take part.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * \- Patients aged 18-45 years with no sex predilection * Medically free Patients with no systemic conditions that can affect post operative pain response. * Patients should not be taking any pain medications 24 hours before intervention * Positive patients' acceptance for participating in the study * Patient able to sign informed consent * Permanent mandibular molars diagnosis with Symptomatic Apical Periodontitis * Permanent molars without any anatomical variations or severe curvatures Exclusion Criteria: * \- Medically compromised patients * Patients who have received antibiotic therapy within the last 2 weeks. * Pregnant or lactating women. * Patients with known allergy to any of the irrigants used. * Patients with swelling or acute peri-apical abscess or fistulous tract. * Teeth that have: * Wide or open apex . * Vital pulp tissue . * Periodontally affected with grade 2or 3 mobility. * Non restorable teeth . * Abnormal anatomy and calcified canals . * Pervious root canal treatment. * severe curved canal * Buccolingual and mesiodistal radiographs were taken to evaluate the root canal anatomy
What this study is about
In the sponsor’s own words, from the registry.
Clinical Evaluation of the Postoperative Pain and Substance P levels Following the use of Bioceramic verses Calcium Hydroxide Intracanal Medicaments in Permanent Mandibular molars with Symptomatic Apical Periodontitis
Study sites(1)
Future University in Egypt - Faculty of Oral and Dental Medicine
Cairo, Egypt
Recruiting
Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07585721. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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