A Study of Ulonivirine (MK-8507) and Methadone in Healthy Volunteers (MK-8507-019)
A Clinical Trial to Study the Effect of a Single Dose of Ulonivirine on the Pharmacokinetics of Methadone
- Healthy
At a glance
- Phase
- Phase 1
- Study type
- Interventional
- Sponsor
- Merck Sharp & Dohme LLC
- Enrolment target
- 14
- Started
- 17 August 2026
- Main results due
- 15 January 2027
- Study sites
- 1
- Registry updated
- 23 September 2026
Can you take part?
- Ages 18 years to 65 years.
- Open to any sex.
- Healthy volunteers can take part.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria The main Inclusion Criteria include but are not limited to: * Is in good health * Has a body mass index (BMI) between \>18 and ≤40 kg/m\^2 * Is reliably participating in a methadone maintenance program for at least 2 months prior to Day 1 and is on a documented stable dose of methadone for at least 14 days prior to Day 1 Exclusion Criteria The main Exclusion Criteria include but are not limited to: * Has a history of cancer (malignancy) * Has a history of significant multiple and/or severe allergies, or has had an anaphylactic reaction or significant intolerability to prescription or nonprescription drugs or food * Has tested positive human immunodeficiency virus (HIV) or for a sexually transmitted infection at screening * Is under the age of legal consent
What this study is about
In the sponsor’s own words, from the registry.
This study is designed to determine the effect of ulonivirine (MK-8507) on methadone in the body. Participants will take methadone alone and then methadone with ulonivirine to see if ulonivirine changes how the body processes methadone.
Study sites(1)
Pinnacle Research Group ( Site 0002)
Anniston, Alabama, United States
Recruiting
Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07595263. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
Not the right study?
Answer three questions and see the studies recruiting near you, in plain language.
Find a study for me