A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity
A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO ASSESS THE EFFICACY AND SAFETY OF ONCE-MONTHLY PF-08653944 IN ADULTS WITH OVERWEIGHT OR OBESITY (VESPER-6)
- Obesity
- Overweight and/or Obesity
- Overweight
At a glance
- Phase
- Phase 3
- Study type
- Interventional
- Sponsor
- Pfizer
- Enrolment target
- 954
- Started
- 10 June 2026
- Main results due
- 4 May 2028
- Study sites
- 58
- Registry updated
- 28 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Aged ≥18 years. * BMI of: ≥30 kg/m2 or ≥27.0 kg/m2 to \<30.0 kg/m2 and must have at least 1 of the following weight-related co-morbidities: hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease, or T2D. Exclusion Criteria: * Have a self-reported body weight change greater than 5% within 90 days prior to Screening. * Diagnosis of type 1 diabetes or any other form of diabetes other than T2D. * History of acute or chronic pancreatitis. * Personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN-2).
What this study is about
In the sponsor’s own words, from the registry.
The purpose of this clinical study is to learn about the effects and safety of berobenatide (PF-08653944). This may help people with overweight or obesity lose weight. People in this study may also have type 2 diabetes.
About 950 adults will be in this study. Berobenatide will be compared to a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. Berobenatide or placebo is given by a shot under the skin in the belly area. The objective of the study is to compare the experiences of people receiving berobenatide to those of the people who do not to assess if the study medicine is effective and safe.
People will take part in this study for about 20 months. During this time, they will have about 15 study visits at the site. They will also have 2 study visits over the phone.
Study sites(58)
San Fernando Valley Health Institute
Canoga Park, California, United States
Recruiting
Headlands Research California, LLC
Escondido, California, United States
Recruiting
ImmuniMet, LLC
Modesto, California, United States
Recruiting
Clinical Trials Research
Sacramento, California, United States
Recruiting
University Clinical Investigators, Inc.
Tustin, California, United States
Recruiting
Diablo Clinical Research, Inc.
Walnut Creek, California, United States
Recruiting
Southern California Retina Specialists
West Hills, California, United States
Recruiting
Nature Coast Clinical Research
Crystal River, Florida, United States
Recruiting
West Coast Eye Institute
Lecanto, Florida, United States
Recruiting
South Broward Research
Miramar, Florida, United States
Recruiting
Suncoast Clinical Research, Inc.
New Port Richey, Florida, United States
Recruiting
West Coast Medical Associates
New Port Richey, Florida, United States
Recruiting
Center for Diabetes, Obesity and Metabolism Inc
Pembroke Pines, Florida, United States
Recruiting
Cedar Crosse Research Center
Chicago, Illinois, United States
Recruiting
Northwestern University
Chicago, Illinois, United States
Recruiting
Endeavor Health - Family Medicine Administration
Evanston, Illinois, United States
Recruiting
Endeavor Health- Endocrinology Research
Skokie, Illinois, United States
Recruiting
MediSphere Medical Research Center, LLC
Evansville, Indiana, United States
Recruiting
Monroe Biomedical Research
Louisville, Kentucky, United States
Recruiting
Ascension Saint Agnes Heart Care
Baltimore, Maryland, United States
Recruiting
Aa Mrc Llc
Flint, Michigan, United States
Recruiting
University Of Nebraska Medical Center
Omaha, Nebraska, United States
Recruiting
Albuquerque Clinical Trials, Inc.
Albuquerque, New Mexico, United States
Recruiting
Weill Cornell Medicine - Comprehensive Weight Control Center
New York, New York, United States
Recruiting
Rochester Clinical Research, LLC
Rochester, New York, United States
Recruiting
Medication Management, LLC
Greensboro, North Carolina, United States
Recruiting
Accellacare - Wilmington
Wilmington, North Carolina, United States
Recruiting
Jeffrey Coleman, OD
Wilmington, North Carolina, United States
Recruiting
Midwest Eye Center
Cincinnati, Ohio, United States
Recruiting
Velocity Clinical Research, Mt. Auburn
Cincinnati, Ohio, United States
Recruiting
PlanIt Research, LLC (Monitoring Room)
Houston, Texas, United States
Recruiting
PlanIt Research, LLC
Houston, Texas, United States
Recruiting
VIP Trials
San Antonio, Texas, United States
Recruiting
York Clinical Research, LLC
Norfolk, Virginia, United States
Recruiting
Saraiva & Berlinger Ltda EPP Instituto de Pesquisa Clínica de Campinas
Campinas, São Paulo, Brazil
Recruiting
Fundação Faculdade Regional de Medicina de São José do Rio Preto
São José do Rio Preto, São Paulo, Brazil
Recruiting
CEPIC - Centro Paulista de Investigação Clínica
São Paulo, Brazil
Recruiting
Hospital das Clínicas da Faculdade de Medicina da USP
São Paulo, Brazil
Recruiting
Ocean West Research Clinic
Surrey, British Columbia, Canada
Recruiting
GA Research Associates Ltd.
Moncton, New Brunswick, Canada
Recruiting
Winterberry Research Inc.
Hamilton, Ontario, Canada
Recruiting
The Wharton Medical Clinic Clinical Trials Inc
Hamilton, Ontario, Canada
Recruiting
Canadian Phase Onward Inc.
Toronto, Ontario, Canada
Recruiting
Medical Corporation Heishinkai OCROM Clinic
Suita, Osaka, Japan
Recruiting
Tokyo Center Clinic
Chuo-ku, Tokyo, Japan
Recruiting
Tokyo-Eki Center-Building Clinic
Chuo-ku, Tokyo, Japan
Recruiting
Fukuwa Clinic
Chuo-ku, Tokyo, Japan
Recruiting
Medical Corporation Heishinkai ToCROM Clinic
Shinjuku-ku, Tokyo, Japan
Recruiting
Konyang University Hospital
Daejeon, Daejeon, South Korea
Recruiting
Hallym University Sacred Heart Hospital
Anyang-si, Gyeonggi-do, South Korea
Recruiting
Pusan National University Yangsan Hospital
Yangsan, Gyeongsangnam-do, South Korea
Recruiting
Gachon University Gil Medical Center
Incheon, Incheon-gwangyeoksi, South Korea
Recruiting
Kangbuk Samsung Hospital
Seoul, Seoul- Teukbyeolsi, South Korea
Recruiting
Hospital Universitario Ramón y Cajal
Madrid, Madrid, Comunidad de, Spain
Not yet recruiting
Hospital San Rafael
A Coruña, Spain
Not yet recruiting
Hospital General Universitario Gregorio Marañon
Madrid, Spain
Not yet recruiting
Hospital Universitario QuironSalud Madrid
Pozuelo de Alarcón, Spain
Not yet recruiting
Hospital Universitario Virgen Del Rocio
Seville, Spain
Not yet recruiting
Showing 58 of 58 sites. 53 of the 58 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07595549. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
Not the right study?
Answer three questions and see the studies recruiting near you, in plain language.
Find a study for me