Clinical Study of MK-4884 in Participants With Advanced or Metastatic Solid Tumors (MK-4884-001)
A Phase 1 Open-label, Multicenter Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of MK-4884 in Participants With Advanced/Metastatic Solid Tumors
- Malignant Neoplasm
At a glance
- Phase
- Phase 1
- Study type
- Interventional
- Sponsor
- Merck Sharp & Dohme LLC
- Enrolment target
- 120
- Started
- 18 June 2026
- Main results due
- 4 October 2029
- Study sites
- 9
- Registry updated
- 25 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Has a histologically or cytologically confirmed diagnosis of 1 of the following unresectable (locally advanced) and/or advanced (metastatic) solid tumors: * Colorectal carcinoma (CRC) * Renal cell carcinoma (RCC) that contains a clear cell component (with or without sarcomatoid and/or rhabdoid features) * Nonsquamous non-small cell lung cancer (NSCLC) * Biliary tract cancer (BTC) (intra-or extrahepatic cholangiocarcinoma (CCA)) or gallbladder cancer (GBC) * Has measurable disease by Response Evaluation Criteria In Solid Tumors 1.1 (RECIST 1.1) * Has adequate organ function * Participants with human immunodeficiency virus (HIV) infection must have well controlled HIV on stable antiretroviral therapy (ART) for at least 4 weeks * Participants who are hepatitis B surface antigen (HBsAg) positive are eligible if they have received Hepatitis B virus (HBV) antiviral therapy for at least 4 weeks, and have undetectable HBV viral load * Participants with a history of Hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable Exclusion Criteria: * Has gastrointestinal malabsorption, a surgical procedure or a condition that could affect the absorption of the study drug * Has a history of clinically significant cardiac, cardiovascular and/or cerebrovascular disease * Has a serious nonhealing wound, ulcer, or bone fracture * Has an active infection(s) requiring systemic therapy * HIV-infected participants with a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease * Known additional malignancy that is progressing or has required active treatment within the past 2 years * Has known active central nervous system (CNS) metastases and/or carcinomatous meningitis * Has a history of stem cell/solid organ transplant * Has not adequately recovered from major surgery
What this study is about
In the sponsor’s own words, from the registry.
Researchers are looking for new ways to treat certain types of advanced and/or metastatic solid tumors.
The main goal of this study is to learn about the safety of different doses of MK-4884 and if participants tolerate them.
Study sites(9)
NEXT Oncology ( Site 0151)
San Antonio, Texas, United States
Recruiting
Princess Margaret Cancer Centre ( Site 0004)
Toronto, Ontario, Canada
Recruiting
Centre Hospitalier de l'Université de Montréal-Unit for Innovative Therapies ( Site 0002)
Montreal, Quebec, Canada
Recruiting
Rambam Health Care Campus ( Site 0051)
Haifa, Israel
Recruiting
Rabin Medical Center ( Site 0053)
Petah Tikva, Israel
Recruiting
National Cancer Center Hospital ( Site 0201)
Chūō, Tokyo, Japan
Recruiting
Cantonal Hospital St.Gallen ( Site 0101)
Sankt Gallen, Canton of St. Gallen, Switzerland
Recruiting
CHUV (centre hospitalier universitaire vaudois) ( Site 0103)
Lausanne, Canton of Vaud, Switzerland
Recruiting
Ospedale Regionale Bellinzona e Valli ( Site 0104)
Bellinzona, Canton Ticino, Switzerland
Recruiting
Showing 9 of 9 sites. 9 of the 9 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07600749. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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