The EDC is live today — see what ships now
All studies
NCT07600749From ClinicalTrials.govRecruiting

Clinical Study of MK-4884 in Participants With Advanced or Metastatic Solid Tumors (MK-4884-001)

A Phase 1 Open-label, Multicenter Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of MK-4884 in Participants With Advanced/Metastatic Solid Tumors

  • Malignant Neoplasm

At a glance

Phase
Phase 1
Study type
Interventional
Sponsor
Merck Sharp & Dohme LLC
Enrolment target
120
Started
18 June 2026
Main results due
4 October 2029
Study sites
9
Registry updated
25 September 2026

Can you take part?

  • Aged 18 years and over.
  • Open to any sex.
  • You need the condition being studied — healthy volunteers are not accepted.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria
Inclusion Criteria:

* Has a histologically or cytologically confirmed diagnosis of 1 of the following unresectable (locally advanced) and/or advanced (metastatic) solid tumors:
* Colorectal carcinoma (CRC)
* Renal cell carcinoma (RCC) that contains a clear cell component (with or without sarcomatoid and/or rhabdoid features)
* Nonsquamous non-small cell lung cancer (NSCLC)
* Biliary tract cancer (BTC) (intra-or extrahepatic cholangiocarcinoma (CCA)) or gallbladder cancer (GBC)
* Has measurable disease by Response Evaluation Criteria In Solid Tumors 1.1 (RECIST 1.1)
* Has adequate organ function
* Participants with human immunodeficiency virus (HIV) infection must have well controlled HIV on stable antiretroviral therapy (ART) for at least 4 weeks
* Participants who are hepatitis B surface antigen (HBsAg) positive are eligible if they have received Hepatitis B virus (HBV) antiviral therapy for at least 4 weeks, and have undetectable HBV viral load
* Participants with a history of Hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable

Exclusion Criteria:

* Has gastrointestinal malabsorption, a surgical procedure or a condition that could affect the absorption of the study drug
* Has a history of clinically significant cardiac, cardiovascular and/or cerebrovascular disease
* Has a serious nonhealing wound, ulcer, or bone fracture
* Has an active infection(s) requiring systemic therapy
* HIV-infected participants with a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease
* Known additional malignancy that is progressing or has required active treatment within the past 2 years
* Has known active central nervous system (CNS) metastases and/or carcinomatous meningitis
* Has a history of stem cell/solid organ transplant
* Has not adequately recovered from major surgery

What this study is about

In the sponsor’s own words, from the registry.

Researchers are looking for new ways to treat certain types of advanced and/or metastatic solid tumors.

The main goal of this study is to learn about the safety of different doses of MK-4884 and if participants tolerate them.

Study sites(9)

  • NEXT Oncology ( Site 0151)

    San Antonio, Texas, United States

    Recruiting

  • Princess Margaret Cancer Centre ( Site 0004)

    Toronto, Ontario, Canada

    Recruiting

  • Centre Hospitalier de l'Université de Montréal-Unit for Innovative Therapies ( Site 0002)

    Montreal, Quebec, Canada

    Recruiting

  • Rambam Health Care Campus ( Site 0051)

    Haifa, Israel

    Recruiting

  • Rabin Medical Center ( Site 0053)

    Petah Tikva, Israel

    Recruiting

  • National Cancer Center Hospital ( Site 0201)

    Chūō, Tokyo, Japan

    Recruiting

  • Cantonal Hospital St.Gallen ( Site 0101)

    Sankt Gallen, Canton of St. Gallen, Switzerland

    Recruiting

  • CHUV (centre hospitalier universitaire vaudois) ( Site 0103)

    Lausanne, Canton of Vaud, Switzerland

    Recruiting

  • Ospedale Regionale Bellinzona e Valli ( Site 0104)

    Bellinzona, Canton Ticino, Switzerland

    Recruiting

Showing 9 of 9 sites. 9 of the 9 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT07600749. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

Not the right study?

Answer three questions and see the studies recruiting near you, in plain language.

Find a study for me
Clinical Study of MK-4884 in Participants With Advanced or Metastatic Solid Tumors (MK-4884-001) | Trialion