A Study to Assess the Effect of Empasiprubart on Nerve Morphology by Ultrasound in Adults With Multifocal Motor Neuropathy
An Open-Label, Single-Arm, Phase 1b Study to Evaluate the Effect of Empasiprubart on Nerve Morphology by Ultrasound in Adults With Multifocal Motor Neuropathy
- Multifocal Motor Neuropathy (MMN)
At a glance
- Phase
- Phase 1
- Study type
- Interventional
- Sponsor
- argenx
- Enrolment target
- 60
- Started
- 27 July 2026
- Main results due
- 1 February 2028
- Study sites
- 4
- Registry updated
- 24 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Is at least 18 years old * Diagnosed with MMN * Has an MMN-RODS centile score of ≤90 * Has confirmed nerve thickening in at least 1 nerve per ultrasound measurement Exclusion Criteria: * Besides the indication under study, known autoimmune disease or any medical condition that, in the investigator's opinion, would interfere with an accurate assessment of clinical symptoms of MMN or puts the participant at undue risk.
What this study is about
In the sponsor’s own words, from the registry.
The main purpose of the study is to evaluate empasiprubart use in adults living with Multifocal Motor Neuropathy (MMN). The researchers will evaluate the effect of empasiprubart on the thickness of the nerves, muscle strength, movement, and on the potential improvement of grip strength of the participants in handling objects.
The study consists of an open-label treatment period where all participants will receive empasiprubart intravenously (IV). After the last dose of empasiprubart participants will enter a safety follow-up period for up to 15 months.
The total study duration for each participant will be approximately 29 months.
More information can be found here: clinicaltrials.argenx.com/empasound
Study sites(4)
Pineo Medical Ecosystem
Tbilisi, K'alak'i T'bilisi, Georgia
Recruiting
Aversi Clinic LTD
Tbilisi, Georgia
Recruiting
Jo Ann Medical Center
Tbilisi, Georgia
Recruiting
S. Khechinashvili University Clinic, Ltd.
Tbilisi, Georgia
Recruiting
Showing 4 of 4 sites. 4 of the 4 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07610564. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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