NCT07614776From ClinicalTrials.govRecruiting

A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA® HD (Aflibercept) in Participants With Neovascular Age-related Macular Degeneration

A Randomized, Double-masked, Comparative Clinical Study Evaluating the Efficacy, Safety, and Immunogenicity of ABP 938 8 mg Versus EYLEA® HD (Aflibercept) Delivered Via Intravitreal Injection in Participants With Neovascular Age-related Macular Degeneration

Neovascular Age-related Macular Degeneration
nAMD

At a glance

Phase: Phase 3
Study type: Interventional
Sponsor: Amgen
Enrolment target: 304
Started: 27 May 2026
Main results due: 31 July 2027
Study sites: 69
Registry updated: 29 September 2026

Can you take part?

Aged 50 years and over.
Open to any sex.
You need the condition being studied — healthy volunteers are not accepted.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria

Inclusion Criteria:

* Men or women ≥ 50 years old, capable of giving signed informed consent
* Active, treatment-naïve subfoveal CNV lesions secondary to nAMD including juxtafoveal lesions that affect the fovea as confirmed by SD-OCT and FA in the study eye (SE)
* Total area of CNV (including both classic and occult components) \> 50% of the total lesion area in the SE
* The BCVA letter score ≥ 24 and ≤ 78 letters, in the SE
* Presence of intra and/or subretinal fluid affecting the central subfield of the SE as identified by SD-OCT attributable to active CNV. The central subfield is defined as a circle with a diameter of 1 mm, centered on the fovea

Exclusion Criteria:

Participants are excluded from the study if any of the following criteria apply at either screening or baseline, unless otherwise indicated per protocol:

* Total lesion size \> 12 disc areas (30.5 mm2) including blood, scars, and neovascularization, in the study eye
* Scar, fibrosis, or atrophy involving the central subfield in the study eye
* Scar or fibrosis involving \> 50% of the total lesion in the study eye
* Presence of retinal pigment epithelium tears or rips involving the macula in the study eye
* History of any vitreous hemorrhage ≤ 4 weeks (28 days) before randomization in the study
* Presence of other causes of CNV, including pathologic myopia (spherical equivalent ≥ 8 diopters negative or axial length ≥ 25 mm), ocular histoplasmosis syndrome, angioid streaks, choroidal rupture, or multifocal choroiditis in the study
* Uncontrolled glaucoma (defined as IOP \>25 mmHg despite treatment with anti-glaucoma medication) in the study eye
* History or clinical evidence of DR, DME, idiopathic autoimmune uveitis, or any other vascular disease affecting the retina, other than nAMD in either eye
* Evidence of active extraocular or periocular infection or inflammation (including infectious blepharitis, keratitis, scleritis, or conjunctivitis) in either eye at the time of screening or randomization
* Uncontrolled blood pressure (defined as systolic \>160 mmHg or diastolic \>95 mmHg). Blood pressure needs to be stable for at least 12 weeks (84 days) prior to screening
* Any prior or concomitant ocular or systemic treatment (with an investigational or approved, anti VEGF or anti-VEGF/anti-angiopoietin agent) in the SE, or surgery for nAMD in the SE, except dietary supplements or vitamins
* History or evidence of any other clinically significant disorder, condition, disease or clinical laboratory abnormality that, in the opinion of the investigator or study medical monitor, if consulted, would pose a risk to participant safety or interfere with the study evaluation or results interpretation
* Other protocol-specified exclusion criteria

What this study is about

In the sponsor’s own words, from the registry.

The aim of this trial is to demonstrate similarity in efficacy between ABP 938 8 mg and aflibercept (US) 8 mg by evaluating the change in best corrected visual acuity (BCVA) in participants with neovascular age-related macular degeneration (nAMD)

Study sites(69)

Retina Consultants of Orange County
Fullerton, California, United States
Recruiting
South Coast Retina Center - RCA
Long Beach, California, United States
Recruiting
Retinal Consultants Medical Group, Inc - Modesto (RCA)
Modesto, California, United States
Recruiting
California Eye Specialists Medical Group, Inc
Pasadena, California, United States
Recruiting
Retinal Consultants Medical Group, Inc - Sacramento - Parkcenter Drive (RCA)
Sacramento, California, United States
Recruiting
California Retina Consultants
Santa Barbara, California, United States
Recruiting
Retina Consultants of Southern Colorado (Colorado Springs)- RCA
Colorado Springs, Colorado, United States
Recruiting
Retina Consultants of Southern Colorado (Pueblo)- RCA
Colorado Springs, Colorado, United States
Recruiting
Colorado Retina Associates (RCA)
Lakewood, Colorado, United States
Recruiting
Retina Group of New England
Waterford, Connecticut, United States
Recruiting
Medeye Associates - Research
Miami, Florida, United States
Recruiting
Retina Consultants of Southwest Florida - Naples
Naples, Florida, United States
Recruiting
Advanced Research, LLC
Pensacola, Florida, United States
Recruiting
University Retina - Bedford Park Location
Chicago, Illinois, United States
Recruiting
Retina Associates
Elmhurst, Illinois, United States
Recruiting
Associated Vitreoretinal and Uveitis Consultants
Carmel, Indiana, United States
Recruiting
The Retina Care Center- Baltimore (PRISM Vision Group)
Baltimore, Maryland, United States
Recruiting
Mid Atlantic Retina Specialists
Hagerstown, Maryland, United States
Recruiting
Retina Specialists
Towson, Maryland, United States
Recruiting
Ophthalmic Consultants of Boston
Boston, Massachusetts, United States
Recruiting
Retina Consultants of Minnesota (RCM) - St. Louis Park
Edina, Minnesota, United States
Recruiting
Mississippi Retina Assoc
Madison, Mississippi, United States
Recruiting
The Retina Institute, Research Retina Institute (RCA)
St Louis, Missouri, United States
Recruiting
Envision Ocular, LLC
Bloomfield, New Jersey, United States
Recruiting
Vision Research Center Eye Associates of New Mexico
Albuquerque, New Mexico, United States
Recruiting
Retina Vitreous Surgeons of CNY, PC
Liverpool, New York, United States
Recruiting
Ophthalmic Consultants of Long Island - Research
Oceanside, New York, United States
Recruiting
Long Island Vitreoretinal Consultants(RCA Network)
Scarsdale, New York, United States
Recruiting
North Carolina Retina Associates
Raleigh, North Carolina, United States
Recruiting
NC Retina Associates- RCA
Wake Forest, North Carolina, United States
Recruiting
Midwest Retina - Main Office
Dublin, Ohio, United States
Recruiting
Eye Care Specialists - Kingston
Kingston, Pennsylvania, United States
Recruiting
Retina Consultants of South Carolina, Charleston Neuroscience institute - Blufffon (RCA)
Beaufort, South Carolina, United States
Recruiting
Charleston Neuroscience Institute
Charleston, South Carolina, United States
Recruiting
Palmetto Retina Center - Main (RCA)
Columbia, South Carolina, United States
Recruiting
Retina Consultants of South Carolina, Charleston Neuroscience Institute- Ladson (RCA)
Ladson, South Carolina, United States
Recruiting
Retina Consultants of South Carolina, Charleston Neuroscience Institute- Mount Pleasant (RCA)
Mt. Pleasant, South Carolina, United States
Recruiting
Palmetto Retina Center, Florence (RCA)
West Columbia, South Carolina, United States
Recruiting
Tennessee Retina PC
Nashville, Tennessee, United States
Recruiting
Texas Retina Associates (TRA) - Arlington
Arlington, Texas, United States
Recruiting
Austin Retina Associates - Ophthalmology/Retina
Austin, Texas, United States
Recruiting
Austin Retina Associates
Austin, Texas, United States
Recruiting
Retina Consultants of Texas - Bellaire
Bellaire, Texas, United States
Recruiting
Texas Retina Associates (TRA) - Dallas Main
Dallas, Texas, United States
Recruiting
Texas Retina Associates - Fort Worth
Fort Worth, Texas, United States
Recruiting
Retina Consultants of Texas - Katy Retina Center
Houston, Texas, United States
Recruiting
Retina Consultants of Texas - The Woodlands
Katy, Texas, United States
Recruiting
Retinal Consultants of Texas- San Antonio
San Antonio, Texas, United States
Recruiting
Retina Consultants of Texas - Schertz
Schertz, Texas, United States
Recruiting
Strategic Clinical Research Group, LLC
Willow Park, Texas, United States
Recruiting
Retina Associates of Utah - Retina Specialist
Salt Lake City, Utah, United States
Recruiting
Emerson Clinical Research- Virginia Retina Specialists
Falls Church, Virginia, United States
Recruiting
Vitreoretinal Associates of Washington
Bellevue, Washington, United States
Recruiting
Retina Center NW PLLC
Silverdale, Washington, United States
Recruiting
Spokane Eye Clinic (OCT and optical exam
Spokane, Washington, United States
Recruiting
Visus, spol. s r.o. - Nachod
Náchod, Hradec Králové Region, Czechia
Recruiting
AXON clinical
Prague, Prague, Czechia
Recruiting
Oblastni nemocnice Mlada Boleslav, a.s., nemocnice Stredoceskeho kraje - Klaudianova nemocnice
Mladá Boleslav, Stredoceský Kraj, Czechia
Recruiting
FN Kralovske Vinohrady - Oftalmologicka klinika
Prague, Czechia
Recruiting
Tokyo Medical Center - Ophthalmology
Meguro-ku, Tokyo, Japan
Recruiting

Showing 60 of 69 sites — filter to narrow it down. 69 of the 69 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT07614776. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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