A Clinical Trial of MK-7262 and Enlicitide in Participants With High Lipoprotein(a) (MK-7262-004)
A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MK-7262 as Monotherapy and When Coadministered With Enlicitide Decanoate in Adults With Elevated Lipoprotein(a)
- Lipoprotein(a)
At a glance
- Phase
- Phase 2
- Study type
- Interventional
- Sponsor
- Merck Sharp & Dohme LLC
- Enrolment target
- 750
- Started
- 30 June 2026
- Main results due
- 12 October 2027
- Study sites
- 66
- Registry updated
- 28 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: The main inclusion criteria include but are not limited to the following: * Has Lp(a) ≥ 150 nmol/L * Is receiving an optimized and stable dose of statin for ≥ 30 days with no planned additions, dose changes, or discontinuations through the duration of the study Exclusion Criteria: The main exclusion criteria include but are not limited to the following: * Has a history of homozygous familial hypercholesterolemia (FH), compound heterozygous FH, or double heterozygous FH * Has a history of class IV heart failure, severe ventricular systolic dysfunction, uncontrolled ventricular arrhythmia, markedly prolonged corrected QT interval, untreated hypertension, or a recent coronary, cerebrovascular, or peripheral ischemic event or arterial revascularization * Has human immunodeficiency virus infection, unless the infection is controlled (i.e. undetectable viral load) * Has an active hepatitis C virus infection or active or chronic hepatitis B virus infection * Has a history of nephrotic syndrome * Has severe renal insufficiency * Has received certain therapies in the prohibited timeframe as specified in the protocol * Has active or chronic hepatobiliary or hepatic disease * Has poorly controlled Type 1 or Type 2 diabetes
What this study is about
In the sponsor’s own words, from the registry.
Researchers designed a trial medicine called MK-7262 to lower levels of Lp(a) in the blood. Researchers want to learn about giving MK-7262 with another trial medicine called enlicitide (also known as MK-0616 or enlicitide decanoate). Enlicitide is in a group of medicines that lower the amount of low-density lipoprotein cholesterol (LDL-C).
The goals of this trial are to evaluate:
* if MK-7262 and enlicitide taken together work better than placebo at lowering Lp(a) and LDL-C levels in the blood * if MK-7262 alone works better than placebo at lowering Lp(a) levels in the blood * the safety and tolerability of taking MK-7262 and enlicitide alone and together
Study sites(66)
Advanced Cardiovascular - Alexander City ( Site 0158)
Alexander City, Alabama, United States
Recruiting
AMR Clinical Mobile ( Site 0149)
Mobile, Alabama, United States
Recruiting
National Heart Institute ( Site 0113)
Beverly Hills, California, United States
Recruiting
Headlands Research CTR Lincoln ( Site 0127)
Lincoln, California, United States
Recruiting
Chase Medical Research, LLC ( Site 0163)
Waterbury, Connecticut, United States
Recruiting
Soffer Health Institute ( Site 0123)
Hollywood, Florida, United States
Recruiting
Westside Center for Clinical Research ( Site 0161)
Jacksonville, Florida, United States
Recruiting
Inpatient Research Clinic ( Site 0110)
Miami Lakes, Florida, United States
Recruiting
Clinical Research Trials of Florida ( Site 0101)
Tampa, Florida, United States
Recruiting
Conquest Research LLC ( Site 0140)
Winter Park, Florida, United States
Recruiting
Flourish Research - Bowie ( Site 0106)
Bowie, Maryland, United States
Recruiting
Velocity Clinical Research Rockville ( Site 0146)
Rockville, Maryland, United States
Recruiting
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division ( Site 0132)
Troy, Michigan, United States
Recruiting
Minneapolis Heart Institute - Minneapolis ( Site 0130)
Minneapolis, Minnesota, United States
Recruiting
Montana Medical Research, Inc. ( Site 0156)
Missoula, Montana, United States
Recruiting
New Mexico Clinical Research & Osteoporosis Center ( Site 0119)
Albuquerque, New Mexico, United States
Recruiting
Laurelton Heart Specialist PC ( Site 0155)
Rosedale, New York, United States
Recruiting
Velocity Clinical Research, Durham ( Site 0145)
Durham, North Carolina, United States
Recruiting
Remington-Davis, Inc. ( Site 0107)
Columbus, Ohio, United States
Recruiting
Holston Medical Group ( Site 0117)
Kingsport, Tennessee, United States
Recruiting
Center for Cardiometabolic Disease Prevention/Baylor College of Medicine ( Site 0154)
Houston, Texas, United States
Recruiting
DM Clinical Research ( Site 0115)
Tomball, Texas, United States
Recruiting
Carient Heart & Vascular - Manassas ( Site 0165)
Manassas, Virginia, United States
Recruiting
Rainier Clinical Research Center ( Site 0116)
Renton, Washington, United States
Recruiting
North York Diagnostic and Cardiac Centre ( Site 0203)
North York, Ontario, Canada
Recruiting
Clinique des Maladies Lipidiques de Quebec ( Site 0201)
Québec, Quebec, Canada
Recruiting
Salud SURA Industriales ( Site 0405)
Medellín, Antioquia, Colombia
Recruiting
Clinica de la Costa S.A.S ( Site 0404)
Barranquilla, Atlántico, Colombia
Recruiting
Solano & Terront Servicios Medicos - UNIENDO SAS ( Site 0402)
Bogota, Cundinamarca, Colombia
Recruiting
Regionshospitalet Viborg ( Site 0507)
Viborg, Central Jutland, Denmark
Recruiting
Sanos Clinic - Nordjylland ( Site 0502)
Gandrup, North Denmark, Denmark
Recruiting
OUH Svendborg Sygehus ( Site 0500)
Svendborg, Region Syddanmark, Denmark
Recruiting
Klinikum Konstanz ( Site 0723)
Konstanz, Baden-Wurttemberg, Germany
Recruiting
Ambulantes Herzzentrum Kassel ( Site 0721)
Kassel, Hesse, Germany
Recruiting
Dedicated Research Site FutureMeds ( Site 0719)
Offenbach, Hesse, Germany
Recruiting
Studienzentrum Brinkum - Torsten Drescher & Dr. Lars Pohlmeier ( Site 0712)
Stuhr, Lower Saxony, Germany
Recruiting
Universitaetsklinikum Carl Gustav Carus, Technische Universitaet Dresden' ( Site 0713)
Dresden, Saxony, Germany
Recruiting
zibp GmbH ( Site 0716)
Berlin, Germany
Recruiting
FutureMeds GmbH ( Site 0718)
Berlin, Germany
Recruiting
Charite Universitätsmedizin Berlin Campus Benjamin Franklin ( Site 0714)
Berlin, Germany
Recruiting
Medical Corporation Heishinkai OCROM Clinic ( Site 2403)
Suita, Osaka, Japan
Recruiting
Kumanomae Nishimura Naika Clinic ( Site 2407)
Arakawa City, Tokyo, Japan
Recruiting
Minamino Cardiovascular Hospital ( Site 2406)
Hachiōji, Tokyo, Japan
Recruiting
Kato Clinic of Internal Medicine ( Site 2402)
Katsushika-ku, Tokyo, Japan
Recruiting
Swing Nozaki Clinic ( Site 2405)
Musashino, Tokyo, Japan
Recruiting
Medical Corporation Heishinkai ToCROM Clinic ( Site 2404)
Shinjuku, Tokyo, Japan
Recruiting
Medical Corporation Hakuaikai Wellness Tenjin Clinic ( Site 2400)
Fukuoka, Japan
Recruiting
Midori Clinic ( Site 2401)
Nagasaki, Japan
Recruiting
National Hospital Organization Osaka National Hospital ( Site 2408)
Osaka, Japan
Recruiting
Ziekenhuis Gelderse Vallei ( Site 1106)
Ede, Gelderland, Netherlands
Recruiting
Ziekenhuis St. Jansdal ( Site 1113)
Harderwijk, Gelderland, Netherlands
Recruiting
Bravis Ziekenhuis, locatie Roosendaal ( Site 1102)
Roosendaal, North Brabant, Netherlands
Recruiting
Noordwest Ziekenhuisgroep ( Site 1110)
Alkmaar, North Holland, Netherlands
Recruiting
Antonius Ziekenhuis, locatie D&A Research and Genetics ( Site 1103)
Sneek, Provincie Friesland, Netherlands
Recruiting
Albert Schweitzer Ziekenhuis, locatie Dordwijk ( Site 1101)
Dordrecht, South Holland, Netherlands
Recruiting
Martini Ziekenhuis ( Site 1108)
Groningen, Netherlands
Recruiting
Hospital San Rafael - La Coruña ( Site 1402)
A Coruña, La Coruna, Spain
Recruiting
Vithas Hospital Sevilla ( Site 1401)
Castilleja de la Cuesta, Sevilla, Spain
Recruiting
Hospital Universitari Vall d Hebron ( Site 1403)
Barcelona, Spain
Recruiting
Hospital Clinic de Barcelona ( Site 1419)
Barcelona, Spain
Recruiting
Showing 60 of 66 sites — filter to narrow it down. 66 of the 66 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07614984. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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