Posterosuperior Bundle Pacing for Prevention of Atrial Fibrillation in Patients With Sinus Node Dysfunction
A Prospective, Multicenter, Randomized Controlled Trial Evaluating the Effect of Posterosuperior Bundle Pacing on Atrial Fibrillation Prevention in Patients With Sinus Node Dysfunction
- Pacing Therapy
- Cardiac Pacing
At a glance
- Phase
- Phase not stated
- Study type
- Interventional
- Sponsor
- Shanghai Tong Ren Hospital
- Enrolment target
- 300
- Started
- 25 August 2026
- Main results due
- 1 February 2029
- Study sites
- 10
- Registry updated
- 23 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Age ≥18 years * Indication for permanent pacemaker implantation, including: * Sinus node dysfunction, defined as at least one of the following: * Symptomatic sinus bradycardia * Tachy-brady syndrome * Chronotropic incompetence * Sinus pause / arrest * Atrioventricular block (if present); if ventricular pacing is required, left bundle branch area pacing is planned * Expected survival \>1 year * Panned implantation of a device capable of detecting atrial high-rate episodes * Willing and able to provide informed consent Exclusion Criteria: * Persistent atrial fibrillation (AF) (\>7 days), long-standing persistent AF, permanent AF, or prior atrioventricular node ablation * Prior cardiac implantable electronic device (CIED) requiring replacement, upgrade, or revision * Indication for cardioverter-defibrillator (ICD) or cardiac resynchronization therapy (CRT-D) * Prior cardiac surgery, severe hepatic or renal dysfunction, or other life-threatening systemic diseases * Acute myocardial infarction within 3 months before enrollment * Persistent left superior vena cava or dextrocardia * Pregnant or breastfeeding women, or women of childbearing potential not using effective contraception * Participation in another clinical trial that may interfere * Any condition that, in the opinion of the investigator, makes participation unsuitable
What this study is about
In the sponsor’s own words, from the registry.
This study aims to evaluate whether posterosuperior bundle (PSB) pacing reduces the incidence of atrial fibrillation (AF) in patients with sinus node dysfunction (SND) undergoing pacemaker implantation. Approximately 300 patients will be enrolled and randomized to receive atrial pacing at either the PSB region or the right atrial appendage (RAA). The primary endpoint is the occurrence of AF episodes lasting ≥6 minutes, as detected by device or surface electrocardiogram. Patients will be followed for up to 24 months.
Study sites(10)
China Medical University affiliated AnQing Municipal Hospital
Anqing, Anhui, China
Not yet recruiting
Tongling People's Hospital
Tongling, Anhui, China
Not yet recruiting
Affiliated Hospital of Zunyi Medical College
Zunyi, Guizhou, China
Not yet recruiting
Wuhan Asia General Hospital
Wuhan, Hubei, China
Not yet recruiting
Tong Ren Hospital, Shanghai Jiaotong University School of Medicine
Shanghai, Shanghai Municipality, China
Recruiting
Fudan University affiliated Huadong Hospital
Shanghai, Shanghai Municipality, China
Not yet recruiting
Shanghai Jiaotong University affiliated Shanghai Ninth People's Hospital
Shanghai, Shanghai Municipality, China
Not yet recruiting
Shanghai Jiaotong University affiliated Shanghai Sixth People's Hospital
Shanghai, Shanghai Municipality, China
Not yet recruiting
Shanghai University of Traditional Chinese Medicine affiliated Putuo Hospital
Shanghai, Shanghai Municipality, China
Not yet recruiting
Tongji University School of Medicine affiliated Tongji University
Shanghai, Shanghai Municipality, China
Not yet recruiting
Showing 10 of 10 sites. 1 of the 10 sites on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07645066. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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