NCT07668414From ClinicalTrials.govRecruiting

A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide

Efficacy and Safety of Zenagamtide s.c. Once-weekly Compared to Semaglutide s.c. Once-weekly in Participants With Obesity (AMAZE 7)

Overweight
Obesity

At a glance

Phase: Phase 3
Study type: Interventional
Sponsor: Novo Nordisk A/S
Enrolment target: 650
Started: 22 September 2026
Main results due: 10 October 2028
Study sites: 45
Registry updated: 28 September 2026

Can you take part?

Aged 18 years and over.
Open to any sex.
You need the condition being studied — healthy volunteers are not accepted.

These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.

Read the full eligibility criteria

Inclusion Criteria:

* Male or female (sex at birth).
* Age 18 years or above at the time of signing the informed consent.

Exclusion Criteria:

* Glycated haemoglobin (HbA1c) ≥ 6.5% (48 millimoles per mole \[mmol/mol\]) as measured by the central laboratory at screening.
* History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.
* Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues within 1 year before screening.

What this study is about

In the sponsor’s own words, from the registry.

The purpose of this study is to find out if zenagamtide is safe and effective for treating participants who have excess body weight compared to treatment with semaglutide.

Study sites(45)

First Valley Medical Group
Lancaster, California, United States
Recruiting
Desert Oasis Healthcare
Palm Springs, California, United States
Recruiting
Western University of Health Sciences
Pomona, California, United States
Recruiting
Artemis Insitute for Clin Res
San Diego, California, United States
Recruiting
Med Home Development Grp
Washington D.C., District of Columbia, United States
Recruiting
Encore Medical Research LLC
Hollywood, Florida, United States
Recruiting
NextPhase Research
Hollywood, Florida, United States
Recruiting
Jacksonville Ctr Clin Res
Jacksonville, Florida, United States
Not yet recruiting
PharmaDev Clinical Research Institute LLC
Miami, Florida, United States
Recruiting
South Broward Research LLC
Miramar, Florida, United States
Recruiting
Essence MD Research
Naples, Florida, United States
Not yet recruiting
Florida Inst For Clin Res LLC
Orlando, Florida, United States
Recruiting
Oviedo Medical Research, LLC
Oviedo, Florida, United States
Recruiting
Palm Beach Research Center
West Palm Beach, Florida, United States
Recruiting
Encore Medical Research of Weston
Weston, Florida, United States
Recruiting
Conquest Research
Atlanta, Georgia, United States
Recruiting
Eastside Bariatric and Gen Surg
Snellville, Georgia, United States
Recruiting
Chicago Research Center, Inc
Chicago, Illinois, United States
Not yet recruiting
Endeavor Health
Skokie, Illinois, United States
Recruiting
Midwest Inst For Clin Res
Indianapolis, Indiana, United States
Recruiting
Southern Clin Research
Zachary, Louisiana, United States
Not yet recruiting
Amicis Centers of Clinical Research
St Louis, Missouri, United States
Recruiting
Ichor Research
Syracuse, New York, United States
Recruiting
Southgate Medical Group, LLP
West Seneca, New York, United States
Recruiting
PharmQuest Life Sciences LLC
Greensboro, North Carolina, United States
Not yet recruiting
Piedmont Healthcare/Research
Statesville, North Carolina, United States
Recruiting
Lillestol Research LLC
Fargo, North Dakota, United States
Recruiting
Geisinger Clinic
Danville, Pennsylvania, United States
Recruiting
Medical University Of South Carolina
Charleston, South Carolina, United States
Recruiting
Hillcrest Clinical Research
Simpsonville, South Carolina, United States
Recruiting
Spartanburg Medical Research
Spartanburg, South Carolina, United States
Recruiting
Amarillo Med Spec LLP
Amarillo, Texas, United States
Recruiting
Texas Diabetes & Endocrinology
Austin, Texas, United States
Recruiting
Pinnacle Clinical Research
Brownsville, Texas, United States
Recruiting
Osvaldo A. Brusco MD
Corpus Christi, Texas, United States
Recruiting
UT Southwestern Med Center
Dallas, Texas, United States
Not yet recruiting
Epic Medical Research
DeSoto, Texas, United States
Not yet recruiting
Houston Research Institute
Houston, Texas, United States
Not yet recruiting
The Endocrine Center
Houston, Texas, United States
Not yet recruiting
Sleep Therapy Research Center
San Antonio, Texas, United States
Not yet recruiting
Olympus Clinical Research
Sugar Land, Texas, United States
Not yet recruiting
National Clin Res Inc.
Richmond, Virginia, United States
Recruiting
Gastroent Consult of SW VA
Roanoke, Virginia, United States
Not yet recruiting
Rainier Clin Res Ctr Inc
Renton, Washington, United States
Recruiting
Seattle Clinical Research Center
Seattle, Washington, United States
Recruiting

Showing 45 of 45 sites. 33 of the 45 sites on this study are recruiting right now — a site can stop enrolling while the study as a whole is still open.

Source: ClinicalTrials.gov record NCT07668414. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.

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