Observational, Non-interventional Biomarker and Endotyping Study
Observational Biomarker Study for the Evaluation of Response and Validation of Endotypes in Acute Respiratory Distress Syndrome
- ARDS (Acute Respiratory Distress Syndrome)
At a glance
- Phase
- Phase not stated
- Study type
- Observational
- Sponsor
- Prenosis, Inc.
- Enrolment target
- 1,200
- Started
- 14 September 2026
- Main results due
- December 2028
- Study sites
- 1
- Registry updated
- 28 September 2026
Can you take part?
- Aged 18 years and over.
- Open to any sex.
- You need the condition being studied — healthy volunteers are not accepted.
These are the headline rules only. Every study has a longer list, and whether you are eligible is decided by the research team at the site — never by this page.
Read the full eligibility criteria
Inclusion Criteria: * Age ≥18 years * ARDS Diagnosis (New Global Definition of ARDS) * Timing: Acute onset within 7 days * Radiology: Bilateral pulmonary opacities * Hypoxia: Non-intubated ARDS: PaO2:FIO2\<300mmHg or SpO2:FIO2\<315 (if SpO2\<97%) on HFNO with flow of \>30 L/min or NIV/CPAP with at least 5 cm H2O end-expiratory pressure; or Intubated ARDS: PaO2:FIO2\<300 mm Hg or SpO2:FIO2\<315 (if SpO2\<97%) * ICU admission * Enrolled within 72 hours of meeting inclusion criteria Exclusion Criteria: • Primary cardiogenic pulmonary edema
What this study is about
In the sponsor’s own words, from the registry.
The goal of this observational study is to establish a centralized ARDS biorepository of longitudinal biospecimens and harmonized clinical data, develop unsupervised, therapy-agnostic endotyping algorithms, and develop unsupervised, therapy-specific treatment-prediction algorithms over a 24 month period.
Study sites(1)
Carle Foundation Hospital
Urbana, Illinois, United States
Recruiting
Showing 1 of 1 sites. 1 of the 1 site on this study is recruiting right now — a site can stop enrolling while the study as a whole is still open.
Source: ClinicalTrials.gov record NCT07675265. Trialion does not run this study, is not paid to refer anyone to it, and cannot enrol you. Eligibility is always decided by the research team at the site.
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